摘要
本文测定了38例癫痫病人血清锌、铜及CSF锌含量,其中9例未服药。未服药病人锌、铜测定值与对照组比较无差异,服药病人血铜含量显著高于对照组,血锌与对照组无差异;抗癫痫药物疗效差的11例病人CSF锌显著低于对照组、血清铜/锌值显著高于对照组、血锌亦比控制较好者为低。以上结果提示抗癫痫药物可致血铜增高,某些难治性癫痫病人中枢神经系统内可能存在锌含量不足。
Determinations of Zn and Cu concentrations in blood and Zn in CSF were carried out in 38 patients with epilepsy,among them 99 cases didn't take any antiepileptic drugs (AEDs).Compared with controls the changes of Zn and Cu levels in the patients without treatment were not significant.The serum copper in AEDs treated patients was considerately higher than that in the controls and the serum zinc showed no difference.In 11 of the patients who were not effectively controlled by AEDs,the zinc level in CSF was obviously lower than that in the controls and the serum copper/zinc ratios were much higher than those inthe controls,however,the serum zinc was lower than that in patients effectively controlled by AEDs.The results suggested that AEDs may lead to the increase of serum copper and that some of intractable.Patients with epilepsy may have zinc deficiency in their central nervous system.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1991年第2期95-98,共4页
Chinese Journal of Nervous and Mental Diseases
