期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

3578例ANA、dsDNA和ENA抗体谱联合检测结果分析 被引量：8

暂未订购
导出
摘要 目的探讨ANA、dsDNA和ENA抗体谱联合检测对自身免疫性疾病的诊断意义。方法收集2011~2014年在我院就诊并进行ANA、dsDNA和ENA抗体谱联合检测的患者共3578例,分析检测结果。结果以ANA、dsDNA和ENA抗体谱中≥1种抗体检测结果阳性即为阳性标本,结果显示女性阳性率显著高于男性（P〈0.01）;ANA、dsDNA和ENA抗体谱联合检测结果阳性可见于多种临床疾病,以系统性红斑狼疮（SLE）、类风湿关节炎（RA）、混合性结缔组织病（MCTD）、干燥综合征（SS）多见,其中系统性红斑狼疮最常见;在SLE、RA、MCTD、SS检测中,ANA对抗原的检测较全面,覆盖面广,检测阳性率高,但特异性不强;dsDNA在SLE的诊断中具有重要意义,特异性高,但敏感性差;ENA抗体谱检测阳性率低,特异性强。三者进行联合检测,可以通过互补提高自身抗体的检出率。结论自身免疫性疾病患者体内存在多种自身抗体,联合检测ANA、dsDNA和ENA抗体谱有助于自身免疫性疾病的诊断和鉴别。
作者 刘萍
机构地区 广州军区广州总医院检验科
出处 《西南国防医药》 CAS 2016年第5期559-561,共3页 Medical Journal of National Defending Forces in Southwest China
关键词 ANA DSDNA ENA抗体谱 自身免疫性疾病
分类号 R446.61 [医药卫生—诊断学]
  • 相关文献

参考文献9

  • 1吴希国,刘秀珍,马越.173例系统性红斑狼疮患者ANA﹑ENA和dsDNA抗体的联合检测分析[J].中国卫生检验杂志,2012,22(4):781-782. 被引量：8
  • 2Peterson LK,Wells D,shaw L,et al. Novel method for quantitative ANA measurement using near-infrared imaging [J]. J Immunol Methods,2009,349:1-8.
  • 3Ffitzler MJ. The antinuclear antibody test:last or lasting gasp[J]. Arthritis & Rheumatism,2011,63(1):19-22.
  • 4Watanabe A,Kodera M,Sugiura K. Anti-DFS70 antibodies in 597 healthy hospital workers [J].Arthritis Rheumatism, 2004, 50(3): 892-900.
  • 5Mahler M, Parker T, Peebles CL, et al. Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases [J]. J Rheumatol, 2012,39(11):2104-2110.
  • 6Ganapathy V, Casiano CA. Autoimmunity to the nuclear autoantigen DFS70(LED-GF): What exactly are the autoantibodies trying to tell us[J].Arthritis Rheum, 2004, 50(3):684-688.
  • 7Daniels T,Zhang J,Gutierrez I,et al. Antinuclear autoantibodies in prostate cancer:immunity to LEDGF/p75,a survival protein highly expressed in prostate tumors and cleaved during apoptosis [J]. Prostate,2005,62( 1): 14-26.
  • 8Mahler M, Jennifer TN, Schulte-Pelkum J, et al. Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies[J]. Arthritis Research &Therapy, 2008,10(6): 131-138.
  • 9周卫,邢艳.雌激素及其受体与自身免疫性疾病[J].国际免疫学杂志,2010,33(1):34-37. 被引量：5

二级参考文献26

  • 1郭慧琛,孙世琪,刘在新（审校者）.怀孕对免疫机制的影响[J].国际免疫学杂志,2006,29(1):8-10. 被引量：3
  • 2孙灵芬,张瑾.SLE患者血清学检测的临床诊断价值[J].中国热带医学,2007,7(4):582-583. 被引量：9
  • 3Macho L, Rovensky J, Rodikova Z, et al. Levels of hormones in plasma and in synovial fluid of knee joint of patients with rheumatoid arthritis. Cas Lek Cesk, 2007, 146(3): 292-296.
  • 4Cutolo M, Capellino S, Sulli A, et al. Estrogens and antoimmunity diseases. Ann N Y Acad Sci, 2006, 1089: 538-547.
  • 5Weidler C, Harle P, Schedel J, et al. Patients with rheumatoid arthritis and systemic lupus erythematosus have increased renal excretion of mitogenic estrogens in relation to endogenous antiestrogens. J Rheumatol, 2004, 31 (3) : 489-494.
  • 6Itoh Y, Hayashi H, Miyazawa K, et al. 17beta-estradiol induces IL-1 alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Spl by dissociating histone deacetylase 2 from ERalpha. J Immunol, 2007, 178(5) : 3059-3066.
  • 7Brahn RE, Banqueriqo ML, Lee JK, et al. An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor and basic fibroblast growth factor. J Rheumatol, 2008, 35 (11) : 2119-2128.
  • 8Hirano S, Furutama D, Hanafusa T. Physiologically high concentrations of 17 beta-estrodiol enhance NF-kappaB activity in hunman T cells. Am J Phsiol Requl Inteqr Cornp Physiol, 2007, 292 ( 4 ) : 1465-1471.
  • 9Tanaka I, Morikawa M, Okuse T, et al. Expression and regulation of WISP2 in rheumatoid arthritic synovium. Biochem and Biophys Res Commun, 2005, 334(4) : 973-978.
  • 10Mitani M, Miura Y, Saura R, et al. Estrogen specifically stimulates expression and production of osteoprotegerin from rheumatoid synovial fibroblasts. Int J Mol Med, 2005, 15(5) : 827-832.

共引文献11

同被引文献48

引证文献8

二级引证文献34

西南国防医药
2016年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部