摘要
细胞凋亡是进化保守的重要生物学过程,具有重要的生理和病理作用,如在免疫系统的发育与稳态以及多种疾病(包括肿瘤)的发生、发展、预后及治疗等过程中起重要作用。因此,近年来参与细胞凋亡信号转导的肿瘤坏死因子(TNF)/TNF受体(TNFR)家族的重要成员TNFα/TNFR、Fas/Fas L和TRAIL/TRAILR成为重要的药物靶点,并开发出多个相关靶向药物,尤其是生物药物,其中有些在临床疗效和商业上获得巨大成功。简介参与细胞凋亡信号转导的TNF/TNFR家族重要成员,着重对其通过介导细胞凋亡而发挥的生物学作用及其相关药物研发作一综述,希望对我国的药物研发有所裨益。
Apoptosis is an evolutionarily conserved and primary biological event with crucial roles in physiological and pathological processes, including the development and homestasis of immune system as well as the pathogenesis, development, prognosis and treatment of several diseases such as cancer. Therefore, in recent years, the major tumor necrosis factor （TNF）/TNF receptor （TNFR） family members, TNFct/TNFR, Fas/FasL and TRAIL/TRAILR, involved in apoptosis signal transduction have become important targets for drug development, and a number of the targeted drugs, especially biological pharmaceuticals, have been developed, in which some have achieved great success in clinical efficacy and commercialization. These major TNF/TNFR family members involved in apoptosis signal transduction were introduced, and their biological functions by mediating apoptosis and the development of the related therapeutics were highlighted so as to promote new drug research and development in our country.
出处
《药学进展》
CAS
2016年第4期284-292,共9页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金创新研究群体项目(No.81421091)
深圳市海外高层次人才基金
关键词
肿瘤坏死因子家族
细胞凋亡
药物靶点
生物药物
tumor necrosis factor family
apoptosis
drug target
biological pharmaceuticals
