摘要
目的比较氯吡格雷、阿司匹林单用及双联抗血小板长期治疗对老年冠心病患者经皮冠状动脉介入术（PCI）术后的影响。方法选择我院2012年3月~2015年3月收治96例老年冠心病且行PCI术治疗患者作为研究对象,随机分为A、B、C三组。A组应用阿司匹林行单抗血小板治疗,B组应用氯吡格雷,C组联合阿司匹林与氯吡格雷行双联抗血小板治疗,比较两组治疗前后凝血指标、心血管不良事件发生率、药物不良反应发生率。结果三组经长期抗血小板治疗后,凝血指标PT、a PTT均获得改善,组内前后差异有统计学意义（P0.05）,治疗后,C组PT、a PTT均高于A组与B组,差异有统计学意义（P0.05）。结论老年冠心病患者PCI术后长期予以氯吡格雷、阿司匹林联合抗血小板治疗额有效预防血小板聚集,大幅降低心血管事件发生率,与单抗方案相比预后更佳,安全性高。
Objective To compare the effects of clopidogrel,aspirin dual antiplatelet long term therapy on elderly patients with coronary heart disease after percutaneous coronary interention（ PCI）. Methods 96 cases of elderly patients who had coronary heart disease and received PCI in the hospital during March 2012 to March 2015 were selected as the research objects and were randomly divided into A,B and C of three groups. Group A was given aspirin for sigle antiplatelet therapy while group B was treated with clopidogrel and group C was given combination of aspirin and clopidogrel for dual antiplatelet therapy. blood coagulation indexes,the incidence rate of adverse cardiovascular events and adverse drug reactions were compared between the two groups before and after the treatment. Results After long-term antiplatelet therapy,blood coagulation index PT and a PTT in the three groups were improved. The before and after differences within group were statistically significant（ P〈0. 05）. In terms of comparison between groups,the comparisons among the three groups before the treatment were not statistically significant（ P〈0. 05）. After the treatment,PT and a PTT in group C were significantly higher than those in group A and B and the difference was statistically significant（ P〈0. 05）. The incidence rate of adverse cardiovascular events in group A and group B was 18. 8%（ 6 /32） which was higher than 3. 1% of group C（ 1 /32） and the difference was statistically significant（ P〈0. 05）. The incidence rates of adverse drug reactions in group A,B and C were 15. 6%（ 5 /32）,12. 5%（ 4 /32） and 15. 6%（ 5 /32）,respectively. The pairwise comparison was not statistically significant（ P〈0. 05）. Conclusion For elderly patients with coronary heart disease after PCI,to adopt clopidogrel,aspirin combined with antiplatelet therapy can effectively prevent platelet aggregation and reduce the incidence rate of cardiovascular events.Compared with sigle drug therapy scheme,the prognosis is better,with high safety.
出处
《血栓与止血学》
2016年第2期134-136,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
氯吡格雷
阿司匹林
冠心病
经皮冠状动脉介入术
Clopidogrel
Aspirin
Coronary heart disease
Percutaneous coronary interention
