摘要
目的:探究丹参酮ⅡA对子宫内膜异位症患者血清Bcl-2、Bax、Caspase-3影响。方法:收集我院妇科病房行腹腔镜手术确诊为子宫内膜内异症患者47例,根据治疗方法不同分为对照组23例和治疗组24例,两组患者均实施腹腔镜下内异病灶电灼或巧克力囊肿剔除术,治疗组患者术后给予丹参酮ⅡA磺酸钠注射液治疗,对照组给予同剂量生理盐水治疗,治疗结束后,观察对比两组患者疗效、痛经积分、血清Bcl-2、Bax、Caspase-3水平。结果:与对照组比较:1治疗组患者的临床总有效率较高,差异具有统计学意义(P<0.05);2治疗组患者Bcl-2水平较低,差异具有统计学意义(P<0.05);3治疗组患者的Bax水平较高,差异具有统计学意义(P<0.05);4治疗组患者Caspase-3水平较高,差异具有统计学意义(P<0.05);5治疗组患者痛经积分较低,差异具有统计学意义(P<0.05)。结论:丹参酮ⅡA治疗子宫内膜异位症,使患者血清Bcl-2水平降低,Bax、Caspase-3水平升高,缓解痛经症状,临床疗效佳,预后良好,适宜临床推广。
Objective：To investigate the effect of the serum Bcl-2,Bax and Caspase-3 by tanshinoneⅡA in patients with endometriosis. Method：47 patients with endometriosis and laparoscopic operation from our hospital department of gynaecology ward were selected and divided into the control group 23 cases and the experiment group 24 cases by different treatment. Two groups were both treated by laparoscopic fulguration of endometriotic lesion or chocolate cyst surger. The experiment group added tanshinoneⅡA sodium sulfonate injection. The control group were got same dose physiological saline. The efficacy,dysmenorrhea score,serum Bcl-2,Bax,Caspase-3 levels were compared after treatment. Result：Compared with the control group,the total clinical efficiency were higher（P〈0.05）,the Bcl-2 level were lower（P〈0.05）,the Bax level were higher（P〈0.05）,the Caspase-3 level were higher（P〈0.05）,the dysmenorrhea score were lower（P〈0.05）.Conclusion：The treatment of endometriosis by tanshinoneⅡA,patients with Bcl-2 levels decreased,Bax,Caspase-3 levels were elevated,to ease the symptoms of dysmenorrhea,clinical curative effect is good,the prognosis is good,suitable for clinical promotion.
出处
《辽宁中医药大学学报》
CAS
2016年第5期224-226,共3页
Journal of Liaoning University of Traditional Chinese Medicine
