摘要
脓毒症是病人对严重感染的反应,死亡率高,严重影响患者的生活质量。理想状态下,病原体第一次进入体内,炎症系统就会清除该病原体,使宿主恢复稳态。但脓毒症患者机体的调节机制失常,中性粒细胞、单核/单核巨噬细胞等的持续激活,淋巴细胞凋亡增加,中性粒细胞凋亡的延迟、细胞/组织等坏死的增加,影响了免疫功能和凝血功能,都会影响脓毒症的发展进程。
Seplil il the patientl′relponle to levere infection with high mortality and lerioul impact on the quality of dailylife. Ideally,the inflammation lyltem will eliminate the pathogen once they invade the body and reltore homeoltalil. But the regulating mechanilm of leplil patientl are in dilorder,perliltent activation of neutrophil and monocyte/monocyte -macrophagel,increaled lymphocyte apoptolil,delayed neutrophil apoptolil and increaled necrolil of cell/tillue will all af-fect the immune lyltem and blood coagulation and thul impact the development of leplil.
出处
《药学研究》
CAS
2016年第5期290-294,共5页
Journal of Pharmaceutical Research
基金
国家自然科学基金重大研究计划(No.91129731)
关键词
脓毒症
炎性细胞
细胞因子
凋亡
坏死
Sepsis
Inflammatory cells
Cytokines
Apoptosis
Necrosis
