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树状寡聚乙二醇修饰的苯丙氨酸衍生物的合成与溶液性质研究 被引量：1

Synthesis and solution properties of phenylalaninate derivatives with branching oligoethyleneoxy chains
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摘要 以苯丙氨酸甲酯与含寡聚乙二醇链的间苯二胺缩合,合成了新型含寡聚乙二醇链的氨基酸分子10和11,其结构经~1H NMR,^(13)C NMR,ESI-HRMS表征。利用UV光谱对化合物4、8、11的溶液性质进行了研究,结果表明,化合物11具有低临界溶液温度性质。 A novel thermosensitive amino acid derivative with oligoethyleneoxy chains,was designed and synthesized from L-methyl phenylalaninate and 3,5-diaminobenzoic acid derivative with oligoethyleneoxy chains. The structures were characterized by 1H NMR,13 C NMR,IR and ESI-HR-MS. The solution properties of 4,8,10,11 were investigated by UV-vis. The results showed that 11 exhibited thermosensitivity and LCST properties.
作者 吴鹏超 余攀 王硕 王丹 李良春
机构地区 西南科技大学生命科学与工程学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2016年第5期711-715,共5页 Chemical Research and Application
基金 国家自然科学基金项目(21002099)资助
关键词 苯丙氨酸甲酯 寡聚乙二醇 低临界溶液温度 UV光谱 L-methyl phenylalaninate oligoethyleneoxy chains LCST UV spectrum.
分类号 O621.2 [理学—有机化学]
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参考文献14

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二级参考文献17

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化学研究与应用
2016年 第5期

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