摘要
目的探讨增强型体外反搏治疗(enhanced external counterpulsation,EECP)对缺血性脑卒中患者超敏C反应蛋白(hs-CRP)和内皮素1(ET-1)的影响,为缺血性脑卒中的二级预防提供进一步的临床证据。方法选取缺血性脑卒中住院患者共187例,EECP治疗组95例,对照组92例,治疗组予常规治疗加上36 h的EECP治疗,对照组予常规治疗,分别比较两组在EECP治疗前、治疗36 h后、治疗后1个月hs-CRP及ET-1的差别。结果与治疗前相比,治疗组hs-CRP、ET-1的血清浓度在EECP治疗后均显著减低,(hs-CRP下降60.1%、ET-1下降40.9%),P值均小于0.05。与对照组比较,治疗组在EECP治疗后hs-CRP、ET-1的浓度均显著减低,(hs-CRP下降41.3%、ET-1下降24.3%),P值均小于0.05。治疗后1个月,与对照组比较,治疗组ET-1的浓度明显减低,(43.8%vs 31.8%),P<0.05。治疗后1个月,治疗组hs-CRP的浓度与对照组比较无明显差异,P>0.05,无统计学意义。结论通过EECP治疗,缺血性脑卒中患者的hs-CRP及ET-1血清水平显著下降,且作用持久,EECP治疗可以抑制动脉粥样硬化进程。
ObjectivesTo explore the effects of enhanced external counterpulsation（EECP）on the serum level ofC-reactive protein and endothelin-1 in patients with cerebral ischemic stroke,to provide clinical evidence for the treat-ment and secondary prevention of patients with cerebral ischemic stroke.MethodsTotal 187 patients with ischemicstroke were enrolled measure the serum level of C-reactive protein and endothelin-1, before EECP, after36 hours EECP,and one-month after EECP. Then contrast the difference of these indicators.ResultAfter treatment, the serum levels of C-reactive protein and endothelin-1 in EECP group were obviously decrease and the difference was statistically signifi-can（ths-CRP 60.1% vs. ET-1 40.9%,P0.05）. After treatment, the serum levels of C-reactive protein and endothelin-1in EECP group were obviously decrease than that in the control group and the difference was statistically significant（hs-CRP 41.3% vs. ET-1 24.3%,P0.05）. One-month after EECP, the serum level of endothelin-1 in EECP group wasobviously decrease than that in the control group（43.8% vs. 31.8%,P0.05）. One-month after EECP, there was no signif-icant difference in the serum levels of C-reactive protein between the two groups（P0.05）.ConclusionEECP can obvi-ously reduce the serum levels of C-reactive protein and endothelin-1 in the patients with ischemic stroke, which indi-cates that EECP can slow atherosclerotic process.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2016年第3期129-133,共5页
Chinese Journal of Nervous and Mental Diseases
基金
2015年深圳市知识创新计划基础研究项目(编号:JCYJ20150402145015987)
2014年深圳市福田区公益性科研项目(编号:FTWS2014016)
关键词
增强型体外反搏
超敏C反应蛋白
内皮素1缺血性脑卒中
Enhanced external counterpulsation
Endothelin-1
C-reactive protein
Cerebral ischemic stroke
