摘要
经典的非酒精性脂肪性肝病(NAFLD)的发病机制是"二次打击"学说,但已不能完全解释由肝细胞脂质堆积发展为脂肪性肝炎、肝纤维化等NAFLD进程。近年来提出的"多次打击"学说强调了内质网应激(ERS)在NAFLD发生发展中的重要作用。内质网是细胞内蛋白质、脂质合成的主要场所,内质网功能失衡会引发ERS,造成肝脂质代谢紊乱和肝细胞凋亡,最终导致NAFLD的发生发展。本文综述了ERS及其与非酒精性肝脂质堆积、脂肪性肝炎和肝细胞凋亡的相关性研究进展。
The"two-hit"theory which underlies the mechanism of non-alcoholic fatty liver disease(NAFLD)is difficult to explain the progress of NAFLD from liver lipid accumulation to steatohepatitis,liver fibrosis and the gradually aggravated diseases.Recently the"multiple-hit"theory emphasizes the significance of endoplasmic reticulum stress(ERS)in the progression of NAFLD.The endoplasmic reticulum is a cytoplasmic organella for protein and lipid synthesis.ERS,which can be induced by the unbalance of endoplasmic reticulum homeostasis,plays a critical role in hepatocyte lipid metabolic disorders,Apoptosis and the progression of NAFLD.In this paper,the relevance of ERS and non-alcoholic liver lipid accumulation,steatohepatitis and hepatocyte apoptosis is reviewed.
作者
孔思明
张晓琳
叶菲
KONG Si-ming;ZHANG Xiao-lin;YE Fei(Bejing Key Laboratory of Drug Delivery Technology and Novel Formulations,State Key Laboratory ofBioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academyof Medical Sciences&Peking Union Medical College,Beijing 100050,China)
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2016年第2期234-238,248,共6页
Journal of International Pharmaceutical Research
基金
国家"重大新药创制"科技重大专项资助项目(2012ZX09103-101-063,2012ZX09301002)
天然药物活性物质与功能国家重点实验室开放基金(GTZK201512)
关键词
非酒精性脂肪性肝病
内质网应激
肝脂质堆积
脂肪性肝炎
肝细胞凋亡
non-alcoholic fatty liver disease
endoplasmic reticulum stress
liver lipid accumulation
steatohepatitis
hepatocyte apoptosis
