摘要
原发性胆汁性肝硬化(PBC)是一种以肝内小胆管进行性、非化脓性炎症为特征的慢性胆汁淤积性疾病,可导致肝纤维化及肝硬化。其病因和发病机制尚不清楚,疾病发生和进展认为是多因素的,大多是环境因素作用于遗传易感者。熊去氧胆酸是被认为是唯一有效的治疗药物,但完全应答率不是特别高。结合国内外文献,对PBC诊断和治疗作一简要综述。
Primary biliary cirrhosis （PBC） is a chronic cholestatic liver disease, characterized by progressive non -pyogenic inflammation in the small intrahepatic bile ducts, and can cause hepatic fibrosis and liver cirrhosis. The etiology and pathogenesis of PBC remain un- known. The development and progression of PBC are caused by various factors, and the major factor is environmental factors acting on pa- tients with genetic susceptibility. Ursodesoxycholic acid is thought to be the only effective drug, but the complete response rate remains low. This article reviews the diagnosis and treatment of PBC with reference to the literature in the world.
出处
《临床肝胆病杂志》
CAS
2016年第4期802-805,共4页
Journal of Clinical Hepatology
关键词
肝硬化
胆汁性
诊断
治疗
综述
liver cirrhosis, biliary
diagnosis
therapy
review
