摘要
目的探讨采用三仁汤加减治疗湿热内蕴型功能性消化不良的临床疗效及其机理。方法选取2014年3月~2015年3月奉化市中医医院消化内科收治的经电子纤维结肠镜确诊,且中医辨证为湿热内蕴型功能性消化不良患者120例,将其按照随机数字法分为观察组和对照组,每组60例,观察组给予三仁汤加减治疗;对照组给予西沙比利片10 mg/次,3次/天,餐前0.5 h服用。2组均2周为1个疗程,2个疗程后评价疗效。结果治疗后2组腹胀、暖气、早饱症状积分均显著下降（P〈0.05）,但观察组下降更为明显（P〈0.05）。治疗后2组胃动素（MTL）、胃泌素（GAS）均显著上升（P〈0.05）,但治疗后2组MTL比较差异无统计学意义,但对照组的GAS显著性高于观察组（P〈0.05）。观察组总有效率为91.7%,显著性高于对照组的78.3%（P〈0.05）。随访3个月,观察组复发率3.3%,对照组复发率15%,2组复发率比较差异具有统计学意义（P〈0.05）。治疗期间2组的肝、肾功能及血、尿常规均在正常范围内,因此2组用药均安全可靠。结论三仁汤加减治疗可显著改善患者临床症状,复发率低,其作用机制可能与提高患者胃动素及胃泌素水平和促进胃排空有关。
Objective To investigate clinical curative effect of Sanren Decoction in the treatment of damp-heat type functional dyspepsia and its mechanism. Methods From March 2014 to March 2015 in hospital 120 cases of patients with damp-heat type functional dyspepsia（ FD） were selected and randomly divided into the observation group and the control group（ 60 cases in each group）; The observation group were given sanren decoction treatment（ 2 times per day,early before dinner）,while the control group had xisha Billy（ 10 mg per time,3 times per day,half an hour before meal）.Two groups all had 2 weeks as a period of treatment,and curative effects were evaluated after treatment. Results In the two groups after treatment abdominal distention,heating and early full symptoms integral were all significantly decreased（ P〈0. 05）,but the observation group decreased more obviously（ P〈0. 05）. Two groups after treatment stomach motion element（ MTL）,gastrin-releasing（ GAS） were all significantly increased（ all P〈0. 05）,but after treatment the MTL was similar between the two groups,which had no statistical significance,but in the control group GAS was significantly higher than that in the observation group,which had statistically significant difference（ P〈0. 05）. the total effective rate In the control group was 91. 7% higher than that in the observation group 78. 3%（ P〈0. 05）. After followed-up for 3 months,the recurrence rate in the observation group was 3. 3%,significant higher than that in the control group 15%（ P〈0. 05）. During treatment liver,kidney,blood and urine routine in the two groups were all within the normal range,which were safe and reliable. Conclusion Sanren Decoction treatment could significantly improve the patients＇ clinical symptoms,and have lower recurrence rate,which mechanism may be related to the level of patients with gastric dynamic element,gastric secrete element and gastric emptying.
出处
《中国生化药物杂志》
CAS
2016年第3期102-104,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
浙江省中医药科技计划(2012ZA002)
关键词
三仁汤
湿热内蕴型
功能性消化不良疗效
机理
Sanren Decoction
damp-heat type
functional dyspepsia curative effect
mechanism
