摘要
细胞因子诱导的杀伤(cytokine-induced killer,CIK)细胞是体外扩增的异质性T淋巴细胞,兼具T淋巴细胞的抗肿瘤活性和自然杀伤(natural killer,NK)细胞的非主要组织相容性复合体(major histocompatibility complex,MHC)限制性杀瘤特性。CIK细胞主要通过直接杀伤肿瘤细胞、释放大量炎性因子杀伤肿瘤细胞以及诱导肿瘤细胞凋亡这3种途径发挥抗肿瘤作用,而且可提高机体的免疫力,清除微小残余病灶,降低肿瘤复发率,最终延长患者的生存期。因此,CIK免疫疗法用于肝细胞癌的辅助治疗具有安全、有效的重要价值。本文对CIK细胞在肝癌治疗方面的研究现状进行综述,一方面总结了CIK细胞的来源、扩增方法、对肝癌细胞的杀伤机制以及临床应用现状,另一方面对CIK细胞的应用前景进行展望。
Cytokine-induced killer（CIK） cells are heterogeneity T lymphocytes amplificated in vitro,which have both anti-tumor activity of T lymphocytes and non-major histocompatibility complex（MHC） restrictive anti-tumor effect of natural killer（NK） cells.CIK cells exert the anti-cancer effect mainly through direct killing tumor cells,releasing inflammatory cytokines to kill cancer cells and inducing apoptosis of tumor cells.Moreover,CIK cells can enhance body immunity,eliminate small residual lesions,finally reduce recurrence rate and prolong survival of patients.Therefore,CIK immunotherapy,as an adjuvant therapy for patients with hepatocellular carcinoma（HCC）,is safe and effective.This paper reviews the research status of CIK cells in the treatment of HCC.On the one hand,the sources,amplification methods,anti-tumor mechanisms and clinical application of CIK cells are summarized;on the other hand,the application prospects of CIK cells are prospected in this article.
出处
《肿瘤》
CAS
CSCD
北大核心
2016年第4期474-478,共5页
Tumor
关键词
癌
肝细胞
杀伤细胞
自然
免疫疗法
Carcinoma
hepatocellular
Killer cells
natural
Immunotherapy
