摘要
目的观察复方丹参注射液联合1,6-二磷酸果糖治疗新生儿窒息后心肌损害的临床疗效。方法查阅2014年3月~2015年9月在我院产科窒息复苏后心肌损害患儿50例资料,进行回顾性分析,以下回顾整理的患儿采用的治疗方法都在患儿家属知情的条件下实施的,对采取不同治疗方法,现归类分组为治疗组和对照组,治疗组和对照组患儿各25例。治疗组患儿25例,除常规疗法外,辅助复方丹参注射液联合1,6-果糖二磷酸钠治疗法,对照组患儿25例,仅使用常规疗法进行治疗。治疗期间观察两组患儿临床症状及实验室、相关心肌酶谱辅助检查变化（CK、AST、CK-MB、LDH、HBDH和c Tn I）。其中症状包括心悸、惊厥和皮疹等。结果治疗组患儿的疗效结果明显优于对照组,其总有效率为96.00%,高于对照组的88.00%;且其显效率很显著,多于50%,证明其疗效突出,见效快,说明联合优势显著。两组数据对比分析,差异有统计学意义（x2=1.6524,P=0.0400）;两组患儿治疗后的CK、AST、CK-MB、LDH、HBDH和c Tn I的对比均明显小于治疗前的（P〈0.05）。这说明联合用药治疗效果显著优于单一使用的,直接表明辅助1,6-果糖二磷酸钠的作用较大;两组临床记载显示治疗后均未出现相关心悸、惊厥和皮疹等并发症的情况,说明两组治疗方案对患者治疗后影响都较小。结论复方丹参注射液联合1,6-二磷酸果糖治疗新生儿窒息后心肌损害的临床疗效显著,优于接受常规治疗方法的疗效,故临床上应加强辅助联合该诊治法。
Objective To observe the clinical effect of compound salvia injection combined 1, 6-Diphosphate in the treatment of myocardial damage after neonatal asphyxia. Methods 50 clinical data with myocardial damage post-resuscitation of neonatal asphyxia, who were received and treated in obstetrics department of our hospital from March 2014 to September 2015, were consulted to retrospectively analyzed and were divided into treatment group and control group according to different treatment methods, which had informed the condition by family members of children patients, with 25 cases in each group. 25 children patients in treatment group were treated with compound salvia injection combined 1, 6-Diphosphate besides routine treatment, while 25 children patients in control group were only treated with routine treatment. To observe the clinical symptoms include palpitation, convulsion, rash and etc., the change of laboratory examination and auxiliary examination of correlative myocardial enzymes（CK, AST, CK-MB, LDH, HBDH, c Tn I） of children patients between the two groups during treatment period. ResultsThe effect results of children patients in treatment group was obviously better than which in control group, the total effective rate in treatment group（96.00 %） was obviously higher than which in control group（88.00 %）, the obvious effective rate in treatment group was significantly of over 50%, with extrusive and fast effect, and with signigicantly advantage on combined treatment, the differences was statically significant（x2=1.6524,P=0.0400）. The CK, AST, CKMB, LDH, HBDH, c Tn I of the two groups after treatment were obviously less than which before treatment（P 〈0.05）. The treatment effect of drug combination was significantly better than which of single using, showed that assisted 1, 6-Diphosphate has large effect. There was no complications condition of correlative palpitation, convulsion, rash and etc. appeared after treatment of the two groups, which showed that the treatment methods of the two groups all has little effect after treatment in patients. Conclusion Compound salvia injection combined 1, 6-Diphosphate in the treatment of myocardial damage after neonatal asphyxia has significantly clinical effect, has better effect than conventional treatment methods, the diagnosis and treatment methods of which could be strengthened in clinic.
出处
《中国医药科学》
2016年第3期115-117,121,共4页
China Medicine And Pharmacy
