摘要
目的:探讨帕罗西汀联合认知行为疗法治疗强迫症的临床疗效。方法:选取本院2014年1月-2015年3月收治的90例强迫症患者作为研究对象,采用随机数字表法将其分为治疗组和对照组,每组45例,对照组给予帕罗西汀治疗,治疗组给予帕罗西汀联合认知行为疗法治疗。分别在治疗后1、3、6个月使用Yale-Brown强迫量表(Y-BOCS)和自我和谐量表(SCCS)评估两组的治疗效果,比较两组治疗效果及不良反应发生情况。结果:治疗后1、3、6个月,治疗组Y-BOCS及SCCS评分均优于对照组,比较差异均有统计学意义(P<0.05);两组均未出现严重不良反应,两组总不良反应发生率比较,差异无统计学意义(P>0.05)。结论:帕罗西汀联合认知疗法治疗强迫症疗效显著,优于单一使用帕罗西汀的纯药物疗法,且不良反应少,值得临床推广使用。
Objective：To investigate the clinical efficacy of Paroxetine combined with cognitive behavior treatment for patients with obsessive compulsive disorder.Method：90 cases of obsessive compulsive disorder patients in our hospital from January 2014 to March 2015 were selected and randomly divided into control group and treatment group,with 45 cases in each group.The control group received Paroxetine for treatment.The treatment group received Paroxetine combined with cognitive behavior treatment.1,3 and 6 months after treatment,the clinical efficacy of the two groups were evaluated by Y-BOCS and SCCS.The clinical efficacy and incidence of adverse reactions were compared between the two groups.Result：1,3 and 6 months after treatment,the Y-BOCS and SCCS scores of the treatment group were better than those of the control group,the differences were statistically significant（P〈0.05）.No serious adverse reactions occurred in both groups.There was no statistically significant difference in the incidence of adverse reactions between the two groups（P〉0.05）.Conclusion：Paroxetine combined with cognitive behavior treatment has exact effect for obsessive compulsive disorder,which is better than the single use of Paroxetine.It has little adverse reactions and is worthy of widely using in clinic.
出处
《中国医学创新》
CAS
2016年第10期54-56,共3页
Medical Innovation of China
基金
云浮市科技局科研立项课题(WS1437)
关键词
帕罗西汀
认知行为疗法
强迫症
Paroxetine
Cognitive behavior treatment
Obsessive compulsive disorder
