摘要
由于肥胖及肥胖相关疾病在全球范围内的日益流行,对于人们来说,清楚地认识脂肪组织如何生长变得非常重要。多项研究结果表明,氧化还原敏感转录因子在脂肪细胞分化的过程中起到了关键的作用。通过明确氧化还原敏感转录因子调节脂肪分化的作用机制,可以为干预脂肪分化和肥胖的形成提供理论和实验依据。本文回顾了最近的一些数据来列举包括核因子E2相关因子2(Nrf2),过氧化物酶体增殖物激活受体γ共激活因子-1α(PGC-1α),p53,核因子κB(NF-κB)和叉头转录因子(Fox O)等氧化还原敏感转录因子在脂肪细胞分化中起到的作用,为研究脂肪分化的分子机制和干预肥胖及其相关疾病提供新思路。
In view of the global prevalence of obesity and obesity-related diseases, it is important to clearly understand how adipose tissues develop. A battery of data implicated that the role of redox-sensitive transcriptional factors play an important role in adipocyte differentiation. Understanding of the molecular mechanism of adipocyte differentiation regulated by redox-sensitive transcriptional factors may provide theoretical and experimental foundation for the intervention of adipogenic differentiation and obesity. In this review, the current progress detailing the role of redox-sensitive transcriptional factors in adipocyte differentiation was reviewed such as Nrf2, PGC-1α, p53, NF- κB and Fox O etc. This review provides novel insights into the regulation of adipocyte differentiation by redox-sensitive transcriptional factors and the intervention of obesity and its related disorders.
出处
《现代生物医学进展》
CAS
2016年第7期1379-1385,共7页
Progress in Modern Biomedicine
基金
国家自然科学基金青年项目(31400724)
陕西省自然科学基金青年项目(2014JQ4135)
关键词
氧化还原
转录因子
脂肪分化
Redox
Transcriptional factors
Adipocyte differentiation
