抗PreS_2随访在肝炎、肝癌中的临床意义

The Significance of Detection and Follow-Up of Anti-preS_2 in Viral Hepatitis and Hepatocellular Carcinoma

导出

摘要本文报道209例乙型肝病血清PreS_2检出率为52.6％。肝硬化和肝癌之PreS_2检出率低,与慢活肝比较,有非常显著差异(P<0.01)。慢性肝病、病损严重、检出率低。LEIA法的检出率稍高于ELISA法。这可能是前者通过发光仪放大的结果。PreS_2与HBeAg相平行,表明PreS_2代表病毒复制水平。 152例乙型肝病的抗PreS_2检出率为11.18％。17例抗PreS_2阳性血清中,有3例与PreS_2并存,并存率为17.7％。这可能是HBV持续感染的结果。_本组17例抗PreS_2阳性血清中,除1例HBV DNA阴性外,16例全为阳性,有10例S-ALT升高。随访6年,发现抗PreS_2在各型肝病中的临床意义是不同的。对急性和慢性迁延性肝炎,是恢复指标。在慢活肝、肝硬化和肝癌多表示病情恶化。但若抗PreS_2由阳性转阴,则预示病情转好。抗PreS_2的出现与肝细胞破坏有关。 Sera of 209 patients with viral hapatitis and hepatocellular carcinoma respectivelly were tested forPre-S2and anti-PreS2. The percentage of detection of Pre-S2 and anti-PreS2 were 52.6% and11. 18%, respectively. The rates of both positive PreS2 and anti-PreS2 were 17. 7%. The results of follow-up indicated that the clinical significance of anti-preS2was markedly differente in different liver diseases. It was a good prognostic marker in AH and CPH,but it is a bad one in CAH,Cirrhosis and hepatocellular carcinoma.