摘要
目的探讨丹参及其制剂作用机制及不良反应的特点及规律。方法通过中国期刊全文数据库、维普数据库和万方数据群等数据库检索并查阅国内公开发行的医药期刊有关丹参及其制剂的原始文献数据,并对丹参及其制剂的作用机制及不良反应进行分类、统计和分析。结果丹参及其制剂的作用机制遍及人体各个系统,尤其在心血管系统甚多,而不良反应的发生率随着丹参及其制剂的广泛应用而日趋增多,具体表现为变态反应、心血管系统以及消化系统损害等,其中变态反应发生的比例最高,但没有罕见的不良反应报告。结论丹参及其制剂的作用机制日益成熟,不良反应的发生率呈稳态而上升的趋势,这可能与进一步研究开发丹参及其制剂有关。
Objective It is to investigate the characteristic and rule of the mechanism and adverse drug reactions of Salviae miltiorrhiza and its preparation. Methods The original document data about Salvia miltiorrhiza and its preparations were searched and consulted in domestic public offering of medical journals from CQVIP,China National Knowledge Infrastructure（ CNKI） and Wanfang Databas,and the mechanism and adverse drug reactions were classified,analyzed and evaluate. Results The mechanism of action of Salvia miltiorrhiza was spread throughout various systems of the human body,especially in cardiovascular system very much,and the incidence rate of adverse drug reactions about Salvia miltiorrhiza and its preparation were increased quickly with their wide investigation,allergic reaction appeared most frequently,then was the damage of cardiovascular system and digestive system,and no reports of exceptional adverse drug reactions was appeared. Conclusion The mechanism of Salvia miltiorrhiza and its preparation are maturate increasingly,the trend about the incidence rate of adverse drug reaction is steady and increasingly assurgent,concerned with the salvia miltiorrhiza and its preparation for the further development perhaps.
出处
《现代中西医结合杂志》
CAS
2016年第12期1280-1284,1325,共6页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
丹参
作用机制
不良反应
文献分析
Salvia miltiorrhiza
mechanism of action
adverse drug reaction
literature analysis
