摘要
系统研究了一系列不同类型脂肪族和芳香族1,3-氧杂螺环化合物的合成方法。分别以脂肪族醛(酮)和季戊四醇为原料,对甲苯磺酸为催化剂,在环己烷中回流分水反应,合成了一系列脂肪族1,3-氧杂螺环化合物;以芳香族醛(酮)和季戊四醇为原料,对甲苯磺酸为催化剂,在甲苯中回流分水反应,合成了一系列芳香族1,3-氧杂螺环化合物,化合物结构经1 H NMR,13 C NMR和MS进行表征。与传统方法相比,该方法具有底物适用范围广泛、操作简单、收率较高和环境友好等优点。
The systematically synthetic methods for different aliphatic and aromatic 1,3-oxo-spirocyclic compounds were studied.Aliphatic 1,3-oxo-spirocyclic compounds were synthesized by reflux of pentaerythritol with aliphatic aldehydes or ketones in cyclohexane using p-toluenesulfonic acid as the catalyst.Aromatic 1,3-oxo-spirocyclic compounds were synthesized by reflux of pentaerythritol with aromatic aldehydes or ketones in toluene using p-toluenesulfonic acid as the catalyst.Compared with conventional methods,this process shows some advantages such as extensive substrates,simple operation,high yield and environment friendly.The structures were characterized by 1 H NMR,13 C NMR and MS.
出处
《常州大学学报（自然科学版）》
CAS
2016年第2期24-28,共5页
Journal of Changzhou University：Natural Science Edition
基金
国家自然科学基金资助项目(21572026
21002009)
江苏省高校自然科学研究重大项目(14KJA150002)
