摘要
目的探讨结核药联合利福喷丁对肺结核患者免疫功能、炎症因子、VEGF及MMP-9的影响.方法60例肺结核患者按照随机分组法分为对照组(n=30)和观察组(n=30).对照组采用利福喷丁治疗,观察组在对照组基础上结合结核丸治疗.对比分析2组治疗前和治疗6个月后免疫功能、炎症因子、VEGF及MMP-9水平变化.结果治疗后,2组组CD3+、CD4+、CD4/CD8均较治疗前显著增加(P<0.05);治疗后,观察组CD3+、CD4+、CD4/CD8明显高于对照组(P<0.05);与治疗前相比,2组治疗后INF-γ水平均明显增加(P<0.05),IL-4、CRP、TNF-α水平明显降低(P<0.05);与对照组治疗后相比,观察组INF-γ水平明显较高(P<0.05),而IL-4、CRP、TNF-α水平较低(P<0.05);与治疗前相比,2组治疗后血清MMP-9、VEGF水平明显降低(P<0.05);与对照组治疗后相比,观察组血清MMP-9、VEGF水平明显降低(P<0.05).结论结核药联合利福喷丁可明显改善患者免疫功能、降低炎症反应、降低VEGF及MMP-9水平,从而有效控制病情,具有重要研究意义,值得进一步推广应用.
Objective To investigate the effects of TB drugs combined with rifapentine on the immune function, inflammatory factors, VEGF and MMP- 9 of patients with pulmonary tuberculosis. Methods Sixty cases of tuberculosis patients were randomly divided into control group（ n = 30） and observation group（ n = 30）. The control group was given rifapentine, while the treatment group was given tuberculosis pill treatment based on rifapentine. The immune function, inflammatory factors, VEGF and MMP- 9 levels of patients before and six months after treatment between the two groups. Results After treatment, the levels of CD3＋, CD4＋ and CD4/CD8 of patients in the two groups were increased significantly（ P〈0.05）. After treatment, the levels of CD3＋, CD4＋ and CD4/CD8 of patients in the observation group were significantly higher than those in the control group（ P〈0.05）. Compared with before treatment, after treatment INF- γ levels were significantly increased（ P〈0.05）, IL- 4, CRP, TNF- α levels were significantly lower（ P〈0.05）. Compared to the control groupafter treatment and observation Group INF- γ levels were significantly higher（ P〈0.05）, while IL- 4, CRP,TNF- α levels lower（ P〈0.05）. Compared with before treatment, the serum MMP- 9, VEGF levels were significantly lower after treatment（ P〈0.05）. Compared with the control group, the serum MMP- 9, VEGF levels of patients in the observation group were significantly lower after treatment（ P〈0.05）. Conclusions Tuberculosis drug combined with rifapentine can significantly improve the immune function of TB patients, reduce inflammation, reduce VEGF and MMP- 9 levels, so as to effectively control the disease, has important significance, and is worthy of further application.
出处
《昆明医科大学学报》
CAS
2016年第2期111-114,共4页
Journal of Kunming Medical University
基金
广东省医学科研基金资助项目(A2012438)
