摘要
目的:探讨吲哚美辛栓直肠给药治疗肝癌患者经肝动脉栓塞化疗术后疼痛、发热的临床效果。方法:选取肝癌经肝动脉栓塞化疗术后非感染性发热、疼痛患者180例,采用随机数字表法分为吲哚美辛栓组和常规组(各90例)。常规组给予口服退热止痛药治疗,吲哚美辛栓组给予吲哚美辛栓直肠给药治疗,对比两组患者的止痛、退热效果差异。结果:用药后12、24、48 h两组的体温测定值较用药前均显著降低(P<0.05),用药后48 h吲哚美辛栓组体温为(36.8±0.6)℃,显著低于常规组的(37.0±0.5)℃(P<0.05)。用药后12、24、48 h两组的VAS评分较用药前均显著降低(P<0.05),用药后48 h吲哚美辛栓组视觉模拟疼痛(VAS)评分为(1.50±0.82)分,显著低于常规组的(1.94±0.91)分(P<0.05)。常规组不良反应发生率为6.67%,显著高于吲哚美辛栓组的0(P<0.05)。结论:吲哚美辛栓直肠给药治疗肝癌患者经肝动脉栓塞化疗术后疼痛、发热,较常规口服退热止痛药具有更好的退热镇痛效果、更长的持续时间、更低的不良反应率等优点。
Objective： To explore the effect of indomethacin on pain and fever in patients with liver cancer after transcatheter arterial chemoembolization. Methods： One hundred and eighty cases of liver cancer patients with non- infectious fever and pain after transcatheter arterial chemoembolization were randomly assigned into indomethacin group and conventional group with 90 cases in each group. The conventional group was given conventional treatment of oral antipyretic analgesics,while the indomethacin group was given indomethacin rectal suppository treatment. The analgesic and antipyretic effect was compared between the two groups. Results： After treatment,the patients＇ body temperature was prominently reduced at 12 h,24 h,and 48 h in both groups（ P〈0. 05）. After 48 h of treatment,the body temperature of patients in indomethacin group（ 36. 8 ± 0. 6） ℃ was significantly lower than that in conventional group（ 37. 0 ± 0. 5） ℃（ P〈0. 05）. After 12 h,24 h and 48 h of medication,VAS scores in both groups were significantly lower than those before the treatment（ P〈0. 05）. After treatment for 48 h,VAS scores（ 1. 50 ± 0. 82） in indomethacin group were significantly lower than those in the conventional group（ 1. 94 ± 0. 91）（ P〈0. 05）. The incidence of adverse reactions（ 6. 67%） in conventional group was significantly higher than that in the indomethacin group（ 0）（ P〈0. 05）. Conclusion： Rectal administration of indomethacin suppositories for the treatment of pain and fever in patients with liver cancer after hepatic artery chemoembolization has better and longer antipyretic analgesic effects than the conventional treatment and has less adverse reactions.
出处
《现代医学》
2016年第3期368-371,共4页
Modern Medical Journal
关键词
吲哚美辛栓
肝癌
经导管动脉栓塞化疗
疼痛
发热
indomethacin
hepatocellular carcinoma
transcatheter arterial chemoembolization
pain
fever
