摘要
微小RNA（miRNA）是一类长约22个核苷酸的内源性非编码RNA，它在转录后水平通过翻译抑制或介导靶mRNA的降解来调节基因的表达。近年来研究发现，miRNA参与调节细胞分化、增殖、组织发育及脂质代谢等，与多种疾病的发生密切相关。该文对miRNA生物学作用及其对胎肺、出生后不同阶段肺发育的调控进行综述。
miRNAs are a group of 22 - 25 nucleotides endogenous non-coding RNAs, which regulate gene expression at the post-transcription level by cause the degradation or translational suppression of target mRNAs. In recent years, studies have demonstrated that miRNAs widely participate in cell differentiation, proliferation, organ development and lipid metabolism, and are closely related to the formation of many kinds of diseases. The biological function of miRNAs and their effects on regulating prenatal and postnatal lung development are reviewed in this paper.
出处
《国际儿科学杂志》
2016年第3期173-176,共4页
International Journal of Pediatrics
基金
国家自然科学基金（81471489）
