摘要
目的探讨宫颈鳞状细胞癌中波形蛋白（Vimentin）及Ki-67蛋白的表达及与宫颈鳞状细胞癌的临床病理特征关系,进一步分析两者在宫颈鳞状细胞癌中表达的相关性。方法采用免疫组化SP法检测57例宫颈鳞状细胞癌组织中Vimentin和Ki-67蛋白的表达情况,结合患者的临床病理资料,进行统计学处理分析。结果 57例宫颈鳞状细胞癌组织中,Vimentin阳性表达率为75.4%（43/57）,平均得分为（2.41±1.52）分;Ki-67阳性表达率高达100.0%,平均得分为（4.48±1.59）分。Ki-67在宫颈鳞状细胞癌组织中的阳性表达率显著高于Vimentin,差异有统计学意义（χ^2=15.960,P〈0.01）。Pearson相关性分析表明,宫颈鳞状细胞癌组织中Vimentin与Ki-67表达呈显著正相关（r=0.984,P=0.000）。Ki-67、Vimentin表达均与患者有无局部侵袭、淋巴结转移及肿瘤的分化程度密切相关（P=0.003,0.000,0.017;P=0.001,0.003,0.008）,而与年龄、肿瘤大小和分期无关（P〉0.05）。结论宫颈鳞状细胞癌组织中Ki-67呈高表达,Ki-67、Vimentin表达与肿瘤的发生、转移和分化程度密切相关,对于宫颈癌的治疗具有重要意义。
Objective To investigate the expression of vimentin（ VIM） and Ki-67 protein in patients with cervical squamous cell carcinoma（ CSCC）,and its relationship with the clinical and pathological features,and analyze the correlation between the expression of Vimentin and Ki-67 in cervical carcinoma. Methods The expression of Vimentin and Ki-67 in57 cases of CSCC tissue was detected by using immunohistochemical S-P method. The data was statistically analyzed combined with the clinicopathologic materials. Results In 57 cases of CSCC,the positive rates of cervical Vimentin were75. 4%（43 /57）,the average score statistics for（2. 41 ± 1. 52）;the positive rates of cervical Ki-67 were 100%,the average score statistics for（4. 48 ± 1. 59）;the positive rate of Ki-67 in cervical carcinoma was 100. 0%,higher than Vimentin（75. 4%）（χ^2= 15. 960,P〈0. 01）. Pearson correlation analysis showed that the expression of Vimentin and CSCC in Ki-67 tissues was significantly positively correlated（ r = 0. 984,P = 0. 00）. Ki-67 and Vimentin expression were closely related to the patients＇ local invasion,lymph node metastasis and tumor differentiation（ P = 0. 003,0. 000,0. 017;P = 0. 001,0. 003,0. 008）,but not with age,tumor size and stage（ P〈0. 05）. Conclusion Ki-67 in cervical squamous cell carcinoma tissues has high expression,the expressions of Ki-67 and Vimentin are closely correlate with invasion,metastasis and differentiated degree. This result has important significance for thetreatment of cervical cancer.
出处
《中华全科医学》
2016年第4期600-603,共4页
Chinese Journal of General Practice
