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Hedgehog信号通路Gli家族成员及其在恶性肿瘤中的作用研究进展 被引量:4

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摘要 Gli(包括Gli1、Gli2及Gli3)是Hedgehog(Hh)信号通路下游分子,其作为核转录因子与启动子结合而激活靶基因转录。Gli蛋白在肿瘤发生、侵袭和转移等过程起重要作用。目前已开展以Gli为靶点的肿瘤干预临床试验。本文对Gli家族在肿瘤中的作用及针对Gli靶向干预肿瘤的研究进展进行综述。
作者 沈冰 刘陶文
出处 《广西医学》 CAS 2016年第2期237-239,共3页 Guangxi Medical Journal
基金 广西医疗卫生适宜技术研究与开发项目(S201408-01)
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