摘要
血管内皮细胞除作为血液与间质组织间的屏障外,还可分泌多种活性物质,以保持血管舒张及收缩因子间的平衡,参与血小板功能调节和凝血因子的清除和纤维溶解过程,调节血管平滑肌生长;调节炎症和免疫反应过程。一旦在某种或多种危险因素的作用下发生血管内皮损伤,引起内皮功能障碍,从而导致一系列的病理生理反应、血管重构和斑块形成,因此内皮损伤是动脉粥样硬化发生的始动因素和关键环节。对于动脉粥样硬化事件的预防,在内皮损伤发生之时即应启动,多项研究证实经典抗血小板药物阿司匹林具有显著的内皮保护作用,可显著修复改善内皮依赖性血管舒张功能。现对内皮损伤及阿司匹林的内皮保护作用进展做简要概述,从而强化临床医生对于内皮损伤的认识,在心血管疾病的发生发展过程中及早给予干预,最大程度地延缓疾病的进展。
Vascular endothelial cells,except as a barrier between the blood and interstitial tissue,can secrete a variety of bioactive substances to maintain the balance between vascular relaxation and contraction factors. As well as regulate platelet function,clearance and fibrinolysis of coagulation factor,which can also regulate vascular smooth muscle growth and inflammatory and immune responses. Once the vascular endothelial injury occurred causing endothelial dysfunction due to one or more risk factors,it will result in a series of pathological and physiological reactions,vascular remodeling and plaque formation,so endothelial injury is the initiating factor and key link of atherosclerosis. The prevention of an atherosclerosis event should be initiated at the time of the endothelial injury occurrence. A number of studies have confirmed that the classic antiplatelet drug aspirin possesses significant endothelial protection,which can significantly improve the endothelium dependent vascular relaxation function. In this article,we will offer a brief overview of endothelial injury and the protective effect of aspirin,thereby strengthening understanding of endothelial injury,providing intervention as soon as possible in the development of cardiovascular disease to delay the disease progression to the full extent.
出处
《心血管病学进展》
CAS
2016年第2期164-167,共4页
Advances in Cardiovascular Diseases
关键词
内皮损伤
阿司匹林
内皮保护
Endothelial injury
Aspirin
Endothelial protection
