摘要
超声由于其安全性、无创性和低成本,如今被广泛应用。声动力疗法是指对肿瘤细胞给予声敏剂之后,再用超声照射肿瘤细胞,诱导一系列声-化学反应,激活声敏剂分子,通过增强声动力效应杀伤肿瘤细胞、抑制肿瘤生长的方法。它可以通过影响肿瘤血管的血液供应、凋亡相关基因以及凋亡信号通路等诱导肿瘤细胞的凋亡。此外,它能通过化疗药物,微泡等得到加强。本文就声动力疗法诱导肿瘤细胞凋亡的机制及其研究进展做一综述。
Because of its perceived safety, noninvasiveness and low cost, ultrasound can be applied widely. Sonodynamic therapy（SDT） is a promising approach that uses a sonosensitizers with the cancer cells before the ultrasound, which lead to a serious of bio - effects, sonochemical effects and induce the apoptosis of the cancer cells. It induces the apoptosis of cancer cells through influencing blood vessels of cancer, genes correlating with apoptosis and the signal pathway of cencers. Furthermore,the effects of SDT can be strengthened by microbubbles, chemotherapeutic drugs and so on. In this review,we will focus on the mechanisms and progress of the apoptosis in cancer cells induced by sonodynamic therapy.
出处
《现代肿瘤医学》
CAS
2016年第10期1652-1655,共4页
Journal of Modern Oncology
基金
哈尔滨市科技局优秀学科带头人(编号:2014RFXGJ035)
关键词
声动力疗法
肿瘤细胞
凋亡
sonodynamic therapy, cancer cells, apoptosis
