摘要
目的 探讨乌鲁木齐慢性丙型肝炎（CHC）合并非酒精性脂肪肝（NAFLD）的相关危险因素,为临床早期干预提供依据。方法 选取2012年6月~2015年6月在本院就诊的153例CHC患者作为研究对象,根据有无合并NAFLD分为NAFLD组（64例）和非NAFLD组（89例）,比较两组的性别、年龄、民族、吸烟、高血压、病程、体重指数（BMI）、腹围、HCV基因型、HCVRNA载量、空腹血糖（FPG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、γ-谷氨酰转肽酶（γ-GGT）、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、尿酸等指标,采用Logistic回归分析其独立危险因子。结果 NAFLD组的BMI、腹围、病程、吸烟、HCV基因型、FPG、FINS、HOMA-IR、ALP、γ-GGT、TG、TC水平显著高于非NAFLD组,差异有统计学意义（P〈0.05或P〈0.01）。Logistic回归分析显示,BMI和吸烟是CHC合并NAFLD的独立危险素。结论 乌鲁木齐CHC患者合并NAFLD的相关危险因素包括BMI、腹围、吸烟、病程、HCV基因型、HOMA-IR、ALP、γ-GGT、TG和TC,其中BMI、吸烟是其独立危险因素。
Objective To explore the related risk factor of chronic hepatitis C （CHC） combined with non-alcoholic fatty liver disease （NAFLD） in Urumqi in order to provide the basis for early clinical intervention. Methods 153 patients with CHC in our hospital from June 2012 to June 2015 were selected and divided into the NAFLD group （n=64） and the non-NAFLD group （n=89） according to whether the merger of NAFLD.The indexes of gender,age,ethnicity,smoking, high blood pressure,course of disease,body mass index （BMI）,abdomen circumference,HCV genotype,HCV RNA load, fasting plasma glucose （FPG）,fasting insulin （FINS）,insulin resistance index （HOMA-IR）,alanine transaminase （ALT）,as- pertate aminotransferase （AST）,alkaline phosphatase （ALP）,γ-glutamyltranspeptidase （γ-GGT）,triglyceride （TG）,total cholesterol （TC）,high-density lipoprotein （HDL）,low density lipoprotein （LDL）,and uric acid in the two groups was com- pared,and these indexes were used by Logistic regression analysis for independent risk factors. Results The level of BMI,abdomen circumference,course of disease,smoking,HCV genotype,FPG,FINS,HOMA-IR,ALP,γ-GGT,TG and TC in the NAFLD group was higher than those in the non-NAFLD group respectively,with significant difference （P〈0.05 or P〈0.01）.The result of Logistic regression analysis showed that BMI and smoking were independent risk factors for CHC combined with NAFLD. Conclusion In Urumqi,the associated risk factors of CHC combined with NAFLD contain BMI, abdomen circumference,smoking,course of disease,HCV genotype,HOMA-IR,ALP,γ-GGT,TG and TC,BMI and smoking are independent risk factors.
出处
《中国当代医药》
2016年第7期18-20,23,共4页
China Modern Medicine
关键词
慢性丙型肝炎
非酒精性脂肪肝
危险因素
Chronic hepatitis C
Non-alcoholic fatty liver disease
Risk factor
