摘要
共轭聚合物骨架为离域电子结构,当在侧链引入正电荷基团或者选择性基团时,能与病原微生物通过静电作用或者特异性作用等结合,从而实现对不同病原微生物的识别与成像.此外,共轭聚合物还具有光毒性与暗毒性,光照下直接敏化或者通过能量转移产生活性氧,而且末端带有季铵盐基团具有广谱杀伤能力,所以共轭聚合物可用于病原微生物的杀伤.本文综述了共轭聚合物在病原微生物识别、成像与杀伤领域中的研究进展.
Conjugated polymers are characterized by a delocalized electronic structure along their backbone. When introducing cationic groups or selectively-recognition elements to the side-chains,conjugated polymers can interact with pathogenic microorganism through electrostatic interactions or specific interactions,then realizing the discrimination and imaging of different pathogenic microorganism. In addition,conjugated polymers have light and/or dark killing ability. Under irradiation,conjugated polymers sensitize the production of reactive oxygen species（ROS） by either direct sensitization or indirect sensitization via energy transfer. And the quaternary ammonium terminal groups are confirmed to be capable of killing a variety of microorganisms. So conjugated polymers can be used for the killing of pathogenic microorganism. In this article,we provide a review of the application of conjugated polymers for discrimination,imaging,and killing of pathogenic microorganism.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2016年第2期153-162,共10页
SCIENTIA SINICA Chimica
基金
国家自然科学基金(编号:21373243
21203213)
国家重点基础研究发展计划(编号:2011CB932302
2013CB932800)资助项目
关键词
共轭聚合物
病原微生物
识别
成像
杀伤
conjugated polymers
pathogenic microorganism
discrimination
imaging
killing
