摘要
目的：探讨早期合并应用促大脑代谢药物在酒精所致精神和行为障碍治疗中的作用。方法：将72例使用酒精所致精神和行为障碍的老年患者随机分为早期合并应用促大脑代谢药物配合地西泮、奥氮平治疗组（研究组36例）和单纯使用地西泮、奥氮平治疗组（对照组36例）,给予12周相应的治疗。分别于治疗前及治疗2、4、8、12周采用中文版简易智能状态检查（MMSE）、阳性症状与阴性症状量表（PANSS）、临床疗效总评量表病情严重程度（CGI-SI）、治疗时出现的症状量表（TESS）进行评定;患者出院后随访6及12个月观察患者的社会功能恢复情况及复饮率。结果：研究组和对照组分别有34例和32例完成12周疗程。治疗前两组患者的MMSE、PANSS评分差异无统计学意义;治疗后两组各时间点MMSE评分较前提升、PANSS评分较治疗前明显下降（P均〈0.01）。治疗2~4周末研究组MMSE评分明显高于对照组、PANSS评分明显低于对照组（P均〈0.01）;8~12周两组间各量表评分及疗效比较差异无统计学意义。治疗6及12个月时研究组社会功能恢复情况显著高于对照组（χ^2=4.942,7.675;P均〈0.01）;12个月时复饮率研究组显著低于对照组（χ^2=9.021,P〈0.01）。结论：早期合并应用促大脑代谢药物配合地西泮、奥氮平治疗能够更快地改善使用酒精所致精神和行为障碍患者的记忆及智能情况,提高患者的社会功能恢复程度,降低复饮率。
Objective：To explore the effect of early combination on brain metabolism promoting drugs in the treatment of mental and behavior disorders due to the use of alcohol.Methods：Seventy-two elderly patients with mental and behavior disorders due to the use of alcohol were randomly divided into early combination on brain metabolism promoting drugs combined with diazepam,olanzapine group（study group,n=36）and diazepam,olanzapine group（control group,n=36）and received corresponding treatment for 12 weeks.Before treatment and 2,4,6,8,12 weekend,the patients were assessed by Mini-mental state examination（MMSE）,Positive and negative syndrome scale（PAPSS）,Clinical global impression severit of illness（CGI-SI）and Treatment emergent symptom scale（TESS）,respectively.The social function recovery and re-drinking rate were observed with 6and 12 months follow up.Results：After 12 weeks,34cases in study group and 32 cases in control group had completed treatment.The scores of MMSE,CGI-SI between the two groups before treatment had no statistically significant difference.However,the scores of MMSE of each time point after treatment in the two group were significantly increased than before,PANSS and CGI-SI were significantly decreased than before（all P〈0.01）.The scores of MMSE in study group at 2to 4weekends after treatment were significantly higher than those in control group.PANSS and CGI-SI were significantly lower than those in control group（all P〈0.01）.However,there were no significant differences between the two groups at 8to 12 weekend.After 6and 12 months follow up,the social function recovery in study group were significantly better than those in control group（χ^2=4.942、7.675;P〈0.01）.The re-drinking rate was significantly lower in study group after 12month（χ^2=9.021,P〈0.01）.Conclusion：Early combination on brain metabolism promoting drugs combined with diazepam,olanzapine can improve memory and intelligence quickly in elderly patients with mental and behavior disorders due to the use of alcohol,increase social function recovery,reduce the re-drinking rate.
出处
《中国健康心理学杂志》
2016年第3期329-332,共4页
China Journal of Health Psychology
关键词
酒精所致的精神和行为障碍
促大脑代谢药物
早期合并
老年患者
Mental and behavior disorders due to the use of alcohol
Brain metabolism promoting drugs
Early combination
Elderly patients
