摘要
微小RNA（miRNA）是一类长19～25个核苷酸的小分子RNA,能与特定的mRNA靶向结合,在转录后水平调控基因表达.越来越多的研究表明,miRNA广泛参与了免疫应答的调控,可以通过靶向免疫系统中关键信号转导分子的表达,在多个环节上参与调控免疫耐受 目前miRNA已经成为一种潜在的生物标志物而广泛运用于肿瘤、感染性疾病、自身免疫性疾病以及移植的诊断和预后.如能进一步研究miRNA在移植免疫中的调控机制并确定其靶基因,则有可能成功诱导免疫耐受,进而对器官移植的发展起到巨大的推动作用.
microRNAs combined with specific mRNAs are 19-25 nucleotide-long small-molecule RNA that mediate sequence-dependent post-transcriptional gene expression.Accumulating evidences indicate that microRNAs target critical signal transduction molecules of immune system,and involve in regulation of immune tolerance.Recently,microRNAs have been a potential biomarker,and are widely useded in diagnosis and prognosis of cancer,infectious disease,autoimmune disease,and transplantation.If we can further identify regulatory mechanism of microRNAs and their target genes,which makes possible the successful induction of immune tolerance and exert a huge push on organ transplantation.
出处
《国际外科学杂志》
2016年第1期61-66,共6页
International Journal of Surgery
基金
重庆市卫生计生委医学科研计划项目（2015MSXM123）
关键词
微RNAS
细胞发育
器官移植
免疫耐受
MicroRNAs
Cell development
Organ transplantation
Immune tolerance
