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老年人脑白质疏松患者认知功能检测研究

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摘要 目的探讨老年患者（年龄≥65岁）发生脑白质疏松（IA）的认知功能的改变。方法根据影像学改变选择年龄65岁及以上，轻度LA患者30例，中重度LA患者27例，选择同期年龄、性别、教育程度相匹配的健康老年人35例。应用神经心理学量表评估分析不同程度的LA对认知功能各个认知域的影响。结果3组间在神经心理学测验均有统计学差异（P〈0．01）。轻度LA组和对照组相比较，TMA和TMrr_B用时明显增加，差异存在统计学意义（P=0．027，0．002），而中重度LA组和对照组、中重度LA和轻度LA组相比较，在MMSE，MoCA，AVLT～I，AVLT-Ⅱ，TMT—A，TMT—B，CDT等神经心理学测验均存在统计学差异（P〈0．01）。HAMA，HAMD在各组间均无统计学差异（P〉0．05）。结论轻度LA能引起老年人执行功能下降，中重度LA可引起老年人多个认知域功能下降。
作者 蒋世峰 王晓薇 盛骏骎 王伟良
机构地区 复旦大学附属中山医院青浦分院 上海市徐汇区中心医院
出处 《中国药业》 CAS 2015年第B11期119-121,共3页 China Pharmaceuticals
关键词 老年人 脑白质疏松 认知功能 神经心理学测验
分类号 R741.04 [医药卫生—神经病学与精神病学]
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参考文献10

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中国药业
2015年 第B11期

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