摘要
目的探讨婴幼儿巨细胞病毒感染的临床特点及诊断手段。方法选取2015年1-6月在武汉市妇女儿童医疗保健中心住院治疗的1 200例婴幼儿的临床资料进行分析,经血清HCMV-Ig M抗体测定及经尿HCMV-DNA定量检测确定为巨细胞病毒感染。结果利用酶联免疫吸附试验(ELISA)法测定血清中HCMV-Ig M抗体,用荧光定量PCR(FQ-PCR)法检测尿中HCMV-DNA可诊断HCMV感染。1 200例巨细胞病毒感染婴幼儿中并发心肌损害235例(19.58%),先天性心脏病81例(6.75%);并发肝功能损害145例(12.08%);并发肺气肿77例(6.42%),呼吸功能衰竭103例(8.58%)。结论婴幼儿巨细胞病毒感染以心脏损害最多见,其次是肝脏和肺损害。HCMV感染可累及患儿身体各组织器官,是引起先天性畸形的重要原因。
Objective To explore the clinical features and diagnostic methods of cytomegalovirus infection in infants and young chil- dren. Methods The clinical data of 1 200 hospitalized infants and young children with cytomegalovirus infection from Wuhan were ana- lyzed. The diagnosis was confirmed with detection of serum HCMV-IgM antibody and urine HCMV-DNA quantitative detection. Results ELISA was used to detect serum HCMV-IgM antibody, fluorescence quantitative PCR was used to detect urine HCMV-DNA to confirm the diagnosis of HCMV infection. Among 1 200 infants and young children with cytomegalovirus infection, 235 cases （ 19. 58% ） were found with myocardial damage, 81 cases （6. 75% ） were found with congenital heart disease; 145 cases （ 12. 08% ） were found with liver function dam- age; 77 cases （6.42%） were found with emphysema, 103 cases （ 8.58% ） were found with respiratory function failure. Conclusion A- mong the infants and young children with cytomegalovirus infection, cardiac damage is the most common complication, followed by liver hnd pulmonary damage. HCMV infection may damage every tissue and organ of the infants and young children, which is an important reason cau- sing congenital malformations.
出处
《中国妇幼保健》
CAS
2016年第5期981-982,共2页
Maternal and Child Health Care of China
基金
湖北省卫生厅项目(JX6B96)
关键词
巨细胞病毒感染
心肌损害
先天性畸形
Cytomegalovirus infection
Myocardial damage
Congenital malformation
