摘要
目的:探讨氨溴索治疗对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能、氧化应激和炎症因子的影响。方法:选择我院收治的AECOPD患者90例,根据就诊先后顺序单双号分为观察组和对照组,每组45例,所有患者均给予常规对症治疗,在此基础上,观察组采用氨溴索治疗,连续治疗10d。分别于治疗前后检测肺功能指标:用力肺活量(FVC)、1秒用力呼气容积(FEV1)、1秒用力呼气容积占用力肺活量比值(FEV1/FVC),血清氧化应激指标:丙二醛(MDA)、超氧化物歧化酶(SOD)和血清炎症因子:白细胞介素-6(IL-6)、白细胞介素-10(IL-10)以及肿瘤坏死因子-α(TNF-α)的水平变化。结果:观察组治疗后肺功能指标FEV1、FVC、FEV1/FVC较本组治疗前以及对照组治疗后均明显升高(P<0.05);观察组治疗后氧化应激指标MDA均较治疗前和对照组治疗后明显降低,SOD较治疗前和对照组治疗后明显升高,差异有统计学意义(P<0.05);观察组治疗后促炎因子IL-6、TNF-α均较治疗前和对照组治疗后明显降低,抗炎因子IL-10较治疗前和对照组治疗后明显升高,差异有统计学意义(P<0.05)。结论:氨溴索可明显降低AECOPD患者的炎症反应,对患者氧化应激及肺功能具有明显改善作用,具有积极的临床意义。
Objective： To explore the effect of ambroxol on pulmonary function, oxidative stress and inflammatory cyto kines in patients with acute exacerbation of chronic obstructive pulmonary diseases period （AECOPD）. Methods： A total of 90 AECOPD patients in our hospital were selected and divided into observation group and control group according to the odd and even numbers in the order of visiting doctors, with 45 cases in each group. All patients were given the conventional treatment,while the patients in observation group were treated with ambroxol on this basis for 10 d. The pulmonary function indexes, in- cluding forced vital capacity （FVC）, forced expiratory volume in 1 second （FEV1） and ratio of FEV1 to FVC （FEV1/FVC）, and serum levels of oxidative stress indicators, including malondialdehyde （MDA） and superoxide dismutase （SOD） and serum inflammatory factors, including interleukin-6 （IL-6） and IL-10 and tumor necrosis factor alpha （TNF-α） were detected respec- tively before and after the treatment. Results.. After treatment, the pulmonary function indexes FEV1, FVC, and FEV1/FVC in observation group were significantly higher than those before treatment and those in control group after treatment, with sta- tistically significant difference （P〈0.05）. The oxidative stress indicator MDA in observation group after treatment was signif- icantly lower than that before treatment and that in control group after treatment while the SOD was significantly higher than that before treatment and that in control group after treatment, with statistically significant difference （P〈0.05）. The pro-in- flammatory factor IL-6 and TNF-a after treatment in observation group were significantly lower than those before treatment and those in control group after treatment, while anti-inflammatory factor IL-10 was significantly higher than that before treat- ment and that in control group after treatment, with statistically significant difference （P〈0.05）. Conclusions.. Ambroxol can significantly reduce inflammation, improve oxidative stress and pulmonary function in patients with AECOPD, with a clinically positive significance.
出处
《海南医学院学报》
CAS
2016年第8期754-757,共4页
Journal of Hainan Medical University
基金
新疆维吾尔自治区省级攻关项目(NO.2014123A166)~~
关键词
氨溴索
慢性阻塞性肺疾病急性加重期
肺功能
氧化应激
炎症因子
Ambroxol
Acute exacerbation period of chronic obstructive pulmonary diseases
Pulmonary function
Oxidative stress
Inflammatory cytokines
