摘要
脓毒症和脓毒性休克是全球重症加强治疗病房（ICU）中导致患者死亡的主要原因。大量关于脓毒症病理生理学的研究发现，炎症网络失衡导致了组织损伤和器官衰竭，最终死亡，其中各种黏附分子、趋化因子、细胞因子、蛋白酶、脂质介质、血管活性肽和细胞应激标志物在脓毒症的病理生理过程中起到重要作用。虽然抗炎介质能抵消促炎介质的作用，但持久的免疫调节可能导致宿主并发感染，因此寻求对抗脓毒症的有效治疗方法具有很大的挑战。充分了解脓毒症中促炎介质和抗炎介质之间复杂的相互作用，以及它们在脓毒症信号转导和免疫调节中的相互协同作用，对防控脓毒症具有重要意义。总结近年来国内外关于脓毒症与固有免疫和适应性免疫系统间相联系的介质的最新发现，阐述其对脓毒症的影响，可能在未来会使许多未知的问题得到解答。
Sepsis and septic shock are the major causes of death in intensive care units （ICUs） worldwide. A large amount of studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines, proteases, lipid mediators, vasoactive peptides, and cell stress markers play key roles in pathophysiology of sepsis. Although anti-inflammatory mediators can neutralize the promoting role of pro-inflammatory mediators, but persistent immune regulation may cause host susceptibility to concurrent infections. Therefore, it is a great challenge to seek effective clinical therapy against sepsis. To understand the complicated interplay between pro- and anti-inflammatory agents in sepsis, and their interaction in signal transduction and immune regulation in sepsis constitute vital significance to the prevention and control of sepsis. Sμmmarize the latest findings about mediators associated with sepsis and innate and adaptive immune system at home and abroad in recent years, and illustrate the impact of its effects on sepsis, which may lead to resolution of many unexplored queries in the future.
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2016年第2期188-192,共5页
Chinese Critical Care Medicine
基金
内蒙古自治区高等学校科学技术研究项目（NJZY13248）
关键词
脓毒症
炎症
先天免疫
适应性免疫
细胞因子
Sepsis
Inflammation
Innate immunity
Adaptive immunity
Cytokines
