摘要
目的探讨米诺环素与阿奇霉素联用治疗儿童支原体肺炎的临床效果及安全性。方法选取该院2009年1月至2012年1月收治的支原体肺炎患儿240例,采用随机数字表法分为对照组和米诺环素组,每组各120例。对照组患者采用阿奇霉素序贯治疗;米诺环素组患者使用阿奇霉素-米诺环素转换治疗。比较2组患儿临床治疗总有效率、咳嗽消失时间、发热持续时间、住院时间及肺外并发症发生率等。结果米诺环素组患儿临床治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);咳嗽消失、发热持续、住院时间均少于对照组,差异有统计学意义(P<0.05);皮疹发生率显著低于对照组,差异有统计学意义(P<0.05)。结论米诺环素与阿奇霉素联用治疗儿童支原体肺炎可显著提高疗效,缓解临床症状,缩短病程,且未增加肺外并发症发生风险。
Objective To study the efficacyand safety of treatment with minocycline and azithromycin to mycoplasma pneumonia in children.Methods 240 cases of mycoplasma pneumonia were choosedfrom January 2009 and January 2012 in the hospital,and were divided into control group and minocycline group by the random number table method,120 cases in each group.The control group were treated by azithromycin sequential therapy;minocycline group of patients treated with azithromycin-minocycline conversion.Clinical total effective rate,fever,cough disappeared time duration,length of hospital stay and extrapulmonary complications were compared in two groups of children.Results The clinical total effective rate in children with minocycline group was significantly higher than that in control group,the difference was statistically significant（P〈0.05）;coughing,fever,hospitalization duration were less than that in control group,the difference was statistically significant（P〈0.05）;rash incidence was significantly lower than that in control group,the difference was statistically significant（P〈0.05）.Conclusion Thetreatmenof minocycline with azithromycin combination can significantly improve the curative effect of treatment in children mycoplasma pneumonia,can relieve the clinical symptoms and reduce the course of the disease,and did not increase the risk of pulmonary complications.
出处
《检验医学与临床》
CAS
2016年第4期490-491,494,共3页
Laboratory Medicine and Clinic
关键词
米诺环素
阿奇霉素
支原体肺炎
minocycline
azithromycin
mycoplasma pneumonia
