白细胞介素-10与骨关节炎相关性的研究进展被引量：8

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摘要白细胞介素（interleukin，IL）-10又称细胞因子合成抑制因子，是Mosmann及其合作者于1989年在小鼠Th2细胞中发现的一种细胞因子，能抑制Th1细胞分泌IL-2和γ干扰素（IFN-γ）。IL-10是除了转化生长因子（TGF）-β和IL-35之外具有抗炎特性的重要细胞因子。它是由活化的免疫细胞产生，特别是单核／巨噬细胞和T细胞亚群（包括TR1、调节性T细胞和Th1细胞）。IL-10通过跨膜受体复合物发挥作用，这个跨膜受体复合物由IL-10R1和IL-10R2组成，调节着多种免疫细胞的功能。

作者潘建科郭达刘军杨伟毅洪坤豪黄永明许树柴

机构地区广州中医药大学第二附属医院骨科

出处《广东医学》 CAS 北大核心 2016年第1期146-148,共3页 Guangdong Medical Journal

基金国家自然科学基金资助项目(编号:81473698 81273781) 教育部高等学校博士点科研基金项目(编号:20124425110004) 广东省科技计划项目(编号:2011B031700027) 广东省财政厅-广东省中医院中老年退行性膝关节炎中医药防治管理体系专项项目(编号:[2014]157号) 广东省中医院中医药科学技术研究专项(编号:YK2013B2N19)

关键词白细胞介素-10 骨关节炎相关性调节性T细胞单核/巨噬细胞 IL-10 TH1细胞受体复合物

分类号 R575.2 [医药卫生—消化系统]

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