摘要
脑损伤可导致神经衰退、炎性反应、神经胶质细胞增殖等一系列改变,以及一些膜外分子(extracellular matrix molecules,ECMs)在损伤周边的大量堆积,从而导致损伤区域瘢痕组织形成,影响神经再生。损伤后丝裂原活化蛋白激酶(MAPK)信号通路被激活可促进损伤后胶质细胞的增殖活化,并对炎症因子的产生释放起至关重要的调节作用。本文综述了创伤性脑损伤(traumatic brain injury,TBI)后,MAPK信号通路的活化对中枢神经损伤后胶质细胞增殖的研究进展。
The brain injury may lead to nerve damage, inflammatory response, glial cell proliferation and a series of other physiological changes, such as accumulated extracellular matrix molecules（ECMs） around the lesion site, resulting in the formation of scar tissue, affecting nerve regeneration. After brain injury, the activation of MAPK signal pathway promotes the proliferation and activation of glial cells and also play a crucial role in the regulation of inflammatory factors＇ release and production. We reviewed the relevant research progress on activated MAPK signal pathway and glial cells proliferation after traumatic brain injury.
出处
《解剖科学进展》
2016年第1期83-86,91,共5页
Progress of Anatomical Sciences
基金
国家自然科学基金(81171248)
