摘要
Wnt3a,one of Wnt family members,plays key roles in regulating pleiotropic cellular functions,including self-renewal,proliferation,differentiation,and motility.Accumulating evidence has suggested that Wnt3 a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.In addition,the roles of Wnt3 a signaling can be inhibited by multiple proteins or chemicals.Herein,we summarize the latest findings on Wnt3 a as an important therapeutic target in cancer.
Wnt3a,one of Wnt family members,plays key roles in regulating pleiotropic cellular functions,including self-renewal,proliferation,differentiation,and motility.Accumulating evidence has suggested that Wnt3 a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.In addition,the roles of Wnt3 a signaling can be inhibited by multiple proteins or chemicals.Herein,we summarize the latest findings on Wnt3 a as an important therapeutic target in cancer.
基金
supported by National Natural Science Foundation of China (NSFC)Key Project(81130046 to JZ)
NSFC projects(81171993 and 81272415 to YL,and 81272340 and 81472386 to CNQ)
National Natural Science Foundation of Guangxi Key Projects(2013GXNSFEA053004 to JZ and 2012GXNSFCB053004 to YL)
Guangxi Projects(1355004-5 to JZ)
Guangxi Ministry of Education(201202ZD022 to YL and 201201ZD004 to JZ)
