摘要
目的探讨子宫内膜异位症手术后服用小剂量米非司酮的临床疗效及不良反应。方法将68例子宫内膜异位症术后患者按随机序号方式分为观察组和对照组,各34例。观察组术后给予小剂量米非司酮治疗,对照组术后给予孕三烯酮治疗。结果观察组总有效率为85.29%,明显高于对照组的67.65%(P<0.05);治疗后两组患者孕酮(P)和黄体生成素(LH)水平较治疗前有明显差异(P<0.05),但组间比较,差异无统计学意义(P>0.05);随访中观察组怀孕率为61.76%,显著高于对照组的44.12%(P<0.05);观察组不良反应发生率为5.88%,明显低于对照组的29.41%(P<0.05)。结论对子宫内膜异位症患者,应用小剂量米非司酮治疗不仅可获得较满意的临床疗效,且不良反应较少,适合临床推广。
Objective To evaluate the clinical efficacy of small- dose mifepristone in treating endometriosis after surgery and its adverse reactions. Methods ： 68 cases of patients underwent endometriosis surgery were divided into observation group and control group according to random numbers, 34 cases in each group. The observation group was given a small dose of mifepristone in the postoperative treatment,and the control group received gestrinone. Results The total effective rate of the observation group was 85. 29%,which was significantly better than 67. 65% of the control group（ P〈0. 05）; after treatment, the progesterone（ P） and luteinizing hormone（ LH）of the two groups had statistically significant difference compared with before treatment（ P〈0. 05）,but with no statistically significant difference between the groups（ P〈0. 05）; during the follow up,the observation group＇s pregnancy rate was 61. 67%,which was significantly higher than 44. 12% of control group（ P〈0. 05）; the incidence rate of adverse reactions of the observation group was 5. 88%,which was significantly lower than 29. 41% of the control group（ P〈0. 05）. Conclusion For the clinical treatment of patients with endometriosis, the application of small- dose of mifepristone can not only get a more satisfactory clinical efficacy, but also with fewer adverse reactions,which is worthy of clinical promotion.
出处
《中国药业》
CAS
2016年第1期101-103,共3页
China Pharmaceuticals
