实时动态血糖监测的准确性与血糖和血糖波动的关系被引量：3

The relationship of accuracy of real-time continuous glucose monitoring system with blood glucose and blood glucose fluctuations

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摘要目的初步探讨实时动态血糖监测(RTˉCGM)系统的准确性与血糖及血糖波动关系。方法纳入50例糖尿病患者,均应用RTˉCGM系统连续监测3 d。计算指尖血糖(FSBG)与RTˉCGM探头值的匹配率,用Pearson相关分析及多元线性回归分析分析匹配率与血糖波动参数的相关性。计算不同时间点、不同FSBG点精度的FSBG与对应探头值的相对平均偏差(RAD)和ISO标准。结果匹配率与平均血糖波动幅度(MAGE)呈线性负相关。全天、餐前、餐后、夜间探头值与相应FSBG的RAD分别为1.21%、2.50%、3.75%、2.38%(P<0.05),ISO标准分别为93.90%、95.02%、91.33%、95.04%。血糖(BG)<4.5 mmol/L,4.5≤BG<7.8 mmol/L,7.8≤BG<11.1mmol/L,11.1mmol/L≤BG探头值与相应FSBG的RAD分别为13.80%、3.14%、5.10%、6.81%(P<0.01),ISO标准分别为78.12%、97.19%、92.41%、89.50%。结论RTˉCGM准确性与血糖及血糖波动有关,血糖波动越小,准确率越高;当低血糖或高血糖时,准确性均降低。 Objective To investigate the relationship of accuracy of real-time continuous glucose monitoring system（RTCGM） with blood glucose and blood glucose fluctuations. Methods Total of 50 diabetic patients was included. Patients were monitored for 72 h using RT-CGM. The matching rate of paired values（FSBG/ RT-CGM） were counted,and the correlation of the matching rate with blood glucose fluctuations was analyzed by correlation analysis and multiple linear regression analysis. Furthermore,we calculated RAD,and ISO criteria of paired values（RT-CGM/FSBG）of all-day,fasting,postprandial,and nighttime. Results The matching rate was negatively correlated with the mean amplitucle of glycaemic excursion（MAGE）. Of all day,fasting,postprandial and nighttime,the RAD were 1.21%,2.50%,3.75%,and 2.38%（P0.05）,respectively, and the ISO criteria were 93.90%,95.02%,91.33%,and 95.04%,respectively. For BG4.5 mmol/L,4.5≤BG7.8 mmol/L,7.8≤BG11.1 mmol/L,11.1 mmol/L≤BG,the RAD were 13.80%,3.14%,5.10%,6.81%,respectively（P0.01）,and the ISO criteria were 78.12%,97.19%,92.41%,89.50%,respectively. Conclusions Blood glucose fluctuations influenced the accuracy of RT-CGM sensor values,the smaller of the blood glucose fluctuations,the higher of the accuracy. Accuracy was reduced at hypoglycemia or hyperglycemia.

作者洛佩徐惠花龚敏余芳牛晶晶陈丽华陈隶华周里钢

机构地区上海市浦东医院复旦大学附属浦东医院内分泌科上海市浦东医院科创中心上海市浦东医院营养科

出处《热带医学杂志》 CAS 2015年第12期1622-1624,1628,共4页 Journal of Tropical Medicine

基金国家自然科学基金面上项目(81370932) 上海市教委东方学者基金上海市科委浦江学者基金(PJ[2011]0000839) 美国MERCK IISP基金(#40313 #40309) 浦东新区领先人才项目(PWR12014-06) 上海市中西医结合人才培养项目(ZYSNXD12-RC-ZXY006)

关键词糖尿病实时动态血糖监测相对平均偏差 ISO标准 Diabetic Real-time continuous glucose monitoring Relative absolute difference ISO criteria

分类号 R587.0 [医药卫生—内分泌]

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