摘要
为了对酯化果胶制备的结肠靶向骨架片体外释药性进行评价,以醋酸酯化果胶为结肠靶向给药骨架片的载体材料,研究了粘合剂、酯化时间、载药量、压片压力对药物释放度的影响。研究得出:粘合剂MC,酯化时间10min,载药量0.009g,压片压力8kN,制备的骨架片初始释放度8%,在16h内,释放度达到85%。此时骨架片的释药性能最好。
In order to evaluate colon targeting esterified pectin matrix tablets as colon targeted drug esterified pectin matrix tablets in vitro release, puting acetic acid delivery carrier material, studing the effect of adhesives, reaction time, load dose, tableting pressure on the drug release rate. Concluded.. MC adhesive most suitable, reaction time 10 min, drug loading 0. 009 g, tableting pressure 8 kN, initial release of matrix tablets was 8%, within 16 hours, the release reached 85 %. At this point the release properties were the best.
基金
国家自然科学基金(20864001
31160326)
广西科学研究与技术开发项目(桂科能10100025)
关键词
酯化果胶
结肠
骨架片
体外释药性
esterified pectin, colon, matrix tablets, releasein vitro
