摘要
目的通过对D-二聚体、凝血四项等指标的监测,探讨如何快速、准确、有效的做出脑卒中患者的早期诊断。方法选取我院2014年3月~2015年9月的急性脑卒中患者80例作为观察组,同期于我院做相同检查的健康体检者80例作为对照组。所有课题参与者均常规检测D-二聚体、凝血四项。结果在急性脑卒中患者中,D-二聚体、凝血四项中活化部分凝血活酶时间（APTT）及纤维蛋白原（FIB）等指标升高。与急性缺血性脑卒中患者相比,急性出血性脑卒中患者的D-二聚体水平升高;二者相比差异有统计学意义（P〈0.05）。D-二聚体与脑卒中的发生相关性较强。根据敏感性曲线我们可以得知,当D-二聚体为0.8μg/ml时,敏感性为90%,此时对于急性出血性脑卒中、急性缺血性脑卒中的鉴别诊断率最高。结论 D-二聚体在早期诊断和鉴别脑卒中具有高的灵敏度和特异性。因此,在临床实践中,对于怀疑或确诊为脑卒中的患者,可将D-二聚体作为常规监测指标。
Objective To investigate the early diagnosis of cerebral apoplexy patients with the rapid,accurate and effective diagnosis by the monitoring of D-DI and coagulation four indices. Methods 80 cases of patients with acute stroke from March 2014 to September 2015 in our hospital as observation group,in the same period,80 cases of health examination in our hospital to do the same examination as the control group. All subjects were tested for D-DI,and coagulation four indices. Results In the patients with acute stroke,D-DI and coagulation four indices including activated partial thromboplastin time（APTT）,fibrinogen（FIB） and so on,these index increased significantly. Compared with patients with acute ischemic stroke,the levels of D-DI in patients with acute hemorrhagic stroke were significantly higher than those of the two patients, and the difference was statistically significant（P〈0.05）. D-DI accumulation and the occurrence of cerebral apoplexy were correlated with the occurrence of cerebral apoplexy. According to the sensitivity curve,we can find that the sensitivity was 90%. Conclusion D-DI has significant sensitivity and specificity in the early diagnosis and differential diagnosis of stroke. Therefore, in future clinical practice, the D-DI can be used as a routine monitoring index for patients with suspected or confirmed stroke.
出处
《中国卫生标准管理》
2015年第32期166-167,共2页
China Health Standard Management
关键词
脑卒中
D-二聚体
凝血四项
Cerebral apoplexy
D-DI
Coagulation four indices
