摘要
目的评价右美托咪定在ICU老年患者镇静治疗中的效果及安全性。方法选择ICU需要镇静治疗的老年患者(年龄≥60岁)86例,随机方法分为治疗组(42例)及对照组(44例),分别给予右美托咪定和咪达唑仑镇静治疗,控制镇静水平Ramsay III^IV级,比较两组镇静起效时间、清醒时间、不良反应发生情况。结果两组均能达到镇静评分目标,右美托咪定镇静同时可以唤醒,与咪达唑仑比较,右美托咪定起效慢;清醒所需时间短,较少发生不良反应,差异均有统计学意义(P<0.05,P<0.01)。结论右美托咪定用于ICU老年患者镇静有效且较咪达唑仑更安全。
Objective To evaluate the efficacy and safety of dexmedetomidine for sedative therapy of elderly patients in ICU.Methods Eighty six elderly patients （age 360 years old） who required sedative therapy in ICU were enrolled and randomly divided into two groups. They were treated either with dexmedetomidine （42 cases） or midazolam （44 cases）. Sedation level was maintained at Ramsay score 2 - 4. The onset time,recovery time and the incidence of adverse reactions were monitored. Results In the two groups, expected sedative scores were all obtained. The patients could be simultaneously waked up when dexmedetomidine was used for sedation. When compared with the midazolam group dexmedetomidine had a slower onset sedation, shorter awake time and less adverse reaction. All the differences were statistically significant （P 〈 0.05 and P 〈 0. 01 ）. Conclusion Dexmedetomidine can serve as an effective and safe medication in ICU sedation for elderly patients.
出处
《实用医院临床杂志》
2016年第1期60-63,共4页
Practical Journal of Clinical Medicine
