摘要
目的:探讨氟哌噻吨美利曲辛联合双歧杆菌三联活菌对腹泻型肠易激综合征(IBS-D)患者焦虑抑郁和免疫功能的改善作用。方法:将126例伴有焦虑抑郁状态的IBS-D患者随机分为观察组、对照Ⅰ组和对照Ⅱ组,每组42例。三组均给予马来酸曲美布汀口服,对照Ⅰ组加用氟哌噻吨美利曲辛,对照Ⅱ组加用双歧杆菌三联活菌,观察组则加用氟哌噻吨美利曲辛+双歧杆菌三联活菌。比较治疗前和治疗1个疗程后三组患者IBS生活质量量表(IBS-QOL)、IBS症状严重程度量表(IBS-SSS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、Ig A、Ig G、Ig M、CD3+、CD4+、CD8+、CD4+/CD8+、不良反应和3个月内复发情况。结果:观察组IBS-QOL、IBS-SSS、HAMD和HAMA评分的改善幅度显著大于对照组Ⅰ组和对照Ⅱ组(P<0.05,P<0.01),且对照组Ⅰ组HAMD和HAMA评分的改善幅度显著大于对照Ⅱ组(P<0.05)。观察组Ig A、Ig G、CD4+和CD4+/CD8+的改善幅度显著大于对照Ⅰ组和对照Ⅱ组,且对照Ⅱ组Ig G、CD4+和CD4+/CD8+的改善幅度显著大于对照Ⅰ组(P<0.05,P<0.01)。三组不良反应发生率无显著差异;观察组1个月时复发率和总复发率均显著低于对照Ⅰ组和对照Ⅱ组(P<0.05)。结论:在胃肠动力药基础上联合应用氟哌噻吨美利曲辛和双歧杆菌四联活菌治疗IBS-D患者,可有效减轻焦虑、抑郁状态,提高机体免疫功能,显著改善临床症状,提高生活质量,降低复发率,且安全性较好。
Objective: To explore the improvement of anxiety-depression and immunologic function for flupenthixol and melitracen combined with bifid triple viable on diarrhea-irratable bowel syndrome(IBS-D).Methods:One hundred and twenty-six cases of IBS-D patients with anxiety-depression were divided into observation group(42 cases), control groupⅠ(42 cases)and control groupⅡ(42 cases). Trimebutine Maleate was administrated in three groups, control groupⅠwas added flupenthixol and melitracen, control groupⅡwas added bifid triple viable, while observation group was added flupenthixol and melitracen combined with bifid triple viable. The IBS-QOL, IBS-SSS, HAMD, HAMA, IgA, IgG, IgM, CD3+, CD4+, CD8+, CD4+/CD8+, adverse reaction and recurrence during three months among the three groups before and one course after treatment were compared. Results:The improvements of IBS-QOL, IBS-SSS, HAMD and HAMA in observation group were obviously larger than that in control groupⅠand control groupⅡ(P<0.05,P<0.01), and the improvements of HAMD and HAMA in control groupⅠ were obviously larger than that in control groupⅡ(P<0.05). The improvements of IgA, IgG, CD4+ and CD4+/CD8+ in observation group were obviously larger than that in control groupⅠ and control groupⅡ, and the improvements of IgG,CD4+ and CD4+/CD8+ in control groupⅡwere obviously larger than that in control groupⅠ(P<0.05,P<0.01). There was no significant difference of adverse reaction among the three groups. The recurrence rate one month later and total recurrence rate in observation group were obviously lower than that in control groupⅠ and control groupⅡ(P<0.05).Conclusion:On basis of gastrointestinal excitomotor, flupenthixol and melitracen combined with bifid triple viable for IBS-D can alleviate diarrhea-irratable condition, boost immunologic function, improve clinical symptoms, decrease recurrence rate with high security, and worthwhile for spreading in clinical practice.
出处
《中国医药导刊》
2015年第12期1255-1257,1260,共4页
Chinese Journal of Medicinal Guide
关键词
肠易激综合征
氟哌噻吨
美利曲辛
双歧杆菌三联活菌
免疫功能
焦虑
抑郁
Irratable bowel syndrome
Flupenthixol and melitracen
Bifid triple viable
Immunologic function
Anxiety
Depression
