摘要
目的探索头孢哌酮舒巴坦钠不同给药方案的临床疗效和药物经济学。方法根据说明书提供的药动学参数和美国临床实验室标准化协会药敏MIC解释标准计算不同方案%T〉MIC值,以%T〉MIC值≥50%为标准评估有效性和经济性。分析本院8年常用抗菌药物耐药资料。结果 %T〉MIC值≥50%方案：①1.5 g,q12h组对敏感级;②1.5 g,q8h和3.0 g,q12h组对敏感、中介级;③1.5 g,q6h、3.0 g,q8h和3.0 g,q6h组对敏感、中介、耐药级。3.0 g,q8h组和1.5 g,q6h组%T〉MIC值相似,但后者更低价、高效。头孢哌酮舒巴坦钠治疗病例59例,超说明书用药占89.83%,总有效率为79.24%。结论头孢哌酮舒巴坦钠说明书中q12h用药方案难以适应当前细菌严重耐药状况下临床治疗需求,中重度或多重耐药细菌感染治疗须用q6～8h方案。
OBJECTIVE To explore the clinical efficacy and pharmaceutical economics of different dosing regimens of cefoperazone sodium and sulbactam sodium. METHODS The values of %T〉MIC of different dosing regimens were calculated by referencing the pharmacokinetic parameters of drug introductions and drug sensitive MIC interpretation standard of Clinical and Laboratory Standards Institute. The clinical efficacy and pharmaceutical economics was evaluated by the standard of（%T〉MIC）≥50%. The drug resistance of commonly used antibiotics of our hospital in the 8 years was analysed. RUSULTS Scheme of（%T〉MIC）≥50%： ①1.5 g, q12 h group was sensitive grade; ②1.5 g, q8 h, 3.0 g, q12 h groups were sensitive, medium level; ③1.5 g, q6 h, 3.0 g, q8 h and 3.0 g, q6 h groups were sensitive, medium and drug resistance. The（%T〉MIC） values were basically similar between the 3.0 q8 h group and 1.5 q6 h group, but 1.5 q6 h group was more cheap and efficient. Cefoperazone sodium and sulbactam sodium was used to treat 59 cases. The over instruction rate was 89.83%. The total effective rate was 79.24%. CONCLUSION The drug regimen（q12h） of drug introduction of cefoperazone sodium and sulbactam sodium can not meet the needs of clinical treatment under the situation of serious bacteria resistance. Severe or multiple drug resistant bacterial infections must be administered by q6-8h. The research and legislation of off-label drug use are imperative.
出处
《中国现代应用药学》
CAS
CSCD
2016年第1期110-114,共5页
Chinese Journal of Modern Applied Pharmacy
关键词
头孢哌酮钠舒巴坦钠
药动学/药效学
%T〉MIC
临床药学
药品说明书
给药方案
cefoperazone sodium and sulbactam sodium
pharmacokinetics and pharmacodynamics
%T〉MIC
clinical pharmacy
drug instructions
dosing regimens
