摘要
目的:探讨^(99m)Tc-甲氧基异丁基异腈(methoxyisobutylisomitrile,MIBI)显像参数与局部晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)同步放化疗疗效之间的关联性。方法:23例晚期非小细胞肺癌患者确诊后,即行^(99m)Tc-MIBI早期和延迟肺显像定量计算肺肿瘤摄取比值(ER=早期相肿瘤/健侧正常肺组织摄取比值,DR=延迟相肿瘤/健侧正常肺组织摄取比值)、滞留指数(RI)=(DR—ER)/ER×100%,评价肺肿瘤参数与同步放化疗疗效之间的关系。患者分为同步放化疗有效组和同步放化疗无效组。结果:^(99m)Tc-MIBI显像中,同步放化疗有效组的ER、DR值均显著高于同步放化疗无效组(P均<0.05)。RI值在两组间无明显区别。结论:^(99m)Tc-MIBI显像在评价局部晚期非小细胞肺癌同步放化疗中具有重要的临床价值。
Objective： To investigate if there was a relationship between99mTc-methoxyisobutylisomitrile imaging tumor uptake parameters and the response of radiotherapy and chemotherapy synchronization in patients with locally advanced non-small-small lung cancer（ NSCLC）. Methods： All 23 patients with NSCLC were studied with99mTc-MIBI early and delayed imaging at the time of diagnosis. Regions of interest（ ROI） were placed over the tumors（ T）,contralateral normal lung tissue（ N）. Pulmonary tumor uptake ratios（ ER = early tumor / contralateral normal lung tissue,DR = delayed tumor / contralateral normal lung tissue）,retention index（ RI =（ DR-ER） / ER × 100%） were calculated. The patients were classified as responders and non-responders by a follow-up CT after radiotherapy and chemotherapy synchronization. Results： ER and DR of99mTc-MIBI uptake was significantly higher in responders than in non-responders. There was no significant difference in RI. Conclusion： ER and DR of99mTc-MIBI SPECT might be useful among locally advanced NSCLC in estimating treatment response.
出处
《现代肿瘤医学》
CAS
2016年第4期581-585,共5页
Journal of Modern Oncology
关键词
99mTc-甲氧基异丁基异腈
非小细胞肺癌
同步放化疗
Technetium-99m methoxyisobutylisonitrile
non-small-cell lung cancer
radiotherapy and chemotherapy synchronization
