摘要
研究环孢素对血脂影响的浓度依赖性。方法对16例肾移植术后患者测定术前和术后血脂及环孢素血药浓度。结果在环孢素血药浓度与术后术前血浆胆固醇及甘油三酯差值之间无统计学相关性。但术后血浆胆固醇的增加在高浓度患者中具有统计学显著性(P>0.05)。结论环孢素对肾移植术后患者血脂的影响呈浓度依赖性。
Aim To investigate the concentration-dependent effect of cyclosporine on plasma lipid. Methods Pre-and post-transplant plasma lipid and cyclosporine whole blood concentration were determined in 16 renal transplanted recipients with stable graft function. Results No statistically significant correlations were found between cyclosporine whole blood concentration and plasma cholesterol and triglyceride increase- difference. However, post-tranplant plasma cholesterol level was increased in renal transplanted recipients with high blood concentration of cyclosporine(P<0.05). Conclusion The effect of cyclosporine on plasma lipid in renal transplanted recipient is concentration-dependent.
