摘要
目的:研究比较羟乙基纤维素止血纱布(HEC-AHG)和氧化再生纤维素止血纱布(ORCAHG)两者的理化性质,为临床应用提供支持。方法:实验测定HEC-AHG与ORC-AHG两者的溶解度、溶解速率、pH值、电导率和纤维素酶作用下的降解动力学。结果:HEC-AHG在去离子水和生理盐水中的溶解度和溶解速率分别为12%~15%和6.5~7.2 mg·ml^(-1)·min~(^(-1)),明显高于ORC-AHG0.08%~0.1,4×10^(-5)~64×10^(-5) mg·ml^(-1)·min^(-1)。HEC-AHG的pH值为6~7,在去离子水中的电导率与纯水(14μS/cm)接近,而ORC-AHG的pH值为2~3,具有较高的电导率(250~450(μS/cm)。室温下HEC-AHG在0.1%纤维素酶作用下降解速率高于ORC-AHG。结论:与ORC-AHG比较,HEC-AHG有更好的溶解性能和较小酸性,降解较快,是一种有前景的新型止血材料。
Objective： To compare the physical and chemical properties of Hydroxyethyl celluloseabsorbable hemostatic gauze（HEC-AHG） and oxidized regenerated celluloseabsorbable hemostatic gauze（ORC-AHG） and provide support for clinical application. Methods： To test the solubility, dissolution rate, pH, conductivity and the degradation kinetics under cellulase enzyme. Results： The study shows that the solubility and dissolution rate of HEC-AHG（12%~15%, 6.5~7.2 mg·ml^（-1）·min^（-1）） are higher than that of ORC-AHG（0.08%~0.1%, 4×10^（-5）~64×10^（-5） mg·ml^（-1）·min^（-1））. The pH value of HEC-AHG is 6~7, and the conductivity of HEC-AHG is close to pure water（14 μS/cm）. While ORC-AHG has the pH value of 2~3 and has higher conductivity（250~450 μS/cm）. In the room temperature, the degradation rate of HEC-AHG is higher than that of ORC-AHG decomposed by cellulase enzyme. Conclusion： Compared to ORC-AHG., HEC-AHG has better solubility, dissolution rate, pH and degradation that indicated HEC-AHG＇s potential hemostatic materials.
出处
《中国医学装备》
2016年第1期114-118,共5页
China Medical Equipment
关键词
羟乙基纤维素
氧化再生纤维素
溶解度
PH值
电导率
降解速率
Hydroxyethyl celluloseabsorbable
Oxidized regenerated celluloseabsorbable
Dissolubility
pH value
Conductivity
Degradation rate
