摘要
目的探讨氨磺必利与氯氮平治疗阴性症状为主的精神分裂症的疗效。方法选取90例以阴性症状为主的精神分裂症患者,按随机数字表分为研究组和对照组各45例。研究组患者采用氨磺必利治疗,对照组采用氯氮平治疗,比较两组患者治疗前、治疗后6周和12周时阴性症状和生活质量改善情况,以及不良反应发生情况。结果研究组治疗总有效率为62.22%,对照组总有效率为64.44%,组间比较差异无统计学意义(P>0.05)。两组患者阴性症状评分(SANS)治疗后均明显下降,与治疗前比较差异均有统计学意义(P<0.05)。其中研究组治疗6周及12周后注意障碍和情感淡漠评分均较对照组低,差异有统计学意义(P<0.05)。治疗后两组患者生活质量评定问卷(GQOLI-74)评分明显增高,与治疗前比较差异有统计学意义(P<0.05)。治疗后研究组社会功能、心理健康和躯体健康评分高于对照组,且差异有统计学意义(P<0.05)。研究组不良反应发生率和不良反应量表(TESS)评分较对照组低,差异有统计学意义(P<0.05)。结论氨磺必利和氯氮平在以阴性症状为主的精神分裂症患者中均有较好治疗效果,但氨磺必利在注意障碍、情感淡漠及生活质量改善方面效果更佳,且有较好安全性。
Objective To investigate the effects of clozapine and amisulpride in treating schizophrenia with predominantly negative symptoms.Methods 90 cases of schizophrenia with predominantly negative symptoms were selected and divided into the research group and the control group according to the random number table,45 cases in each group.The research group adopted the amisulpride treatment,while the control group adopted the clozapine treatment.The improvement situation of negative symptoms and life quality before treatment and in 6,12 weeks after treatment and adverse reactions were compared between the two groups.Results The total effective rate in the research group was 62.22%,which in the control group was 64.44%,no statistically significant difference was found between the two groups（P〈0.05）.The SANS scores of the two group were decreased after treatment,and had statistically significant difference compared with before treatment（P〈0.05）.The scores of attention disorder and apathy after 6-12 week treatment in the research group were lower than those in the control group,the difference was statistically significant（P〈0.05）.The GQOLI-74 score after treatment in the two group were significantly increased and had statistically significant difference compared with before treatment（P〈0.05）.The scores of social function,mental health and physical health after treatment in the research group were higher than those in the control group,the differences were statistically significant（P〈0.05）.The occurrence rate of adverse reactions and TESS score in the research group were lower than those in the control group,the difference was statistically significant（P〈0.05）.Conclusion Clozapine and amisulpride all have good effects in treating schizophrenia with predominantly negative symptoms,but amisulpride has better effect in the aspects of attention disorder,emotional apathy and life quality,moreover has good safety.
出处
《检验医学与临床》
CAS
2016年第2期201-203,206,共4页
Laboratory Medicine and Clinic
