摘要
目的 阿莫西林（ＡＭＰＣ）与庆大霉素（ＧＭ）或奈替木星（ＮＴＬ）联合应用抗生素后效应（ＰＡＥ）的比较。方法 应用光密度法测定ＰＡＥ。结果ＡＭＰＣ单用时对金黄色葡萄球菌和粪肠球菌有较长的ＰＡＥ，对大肠埃希氏菌ＰＡＥ甚小；ＧＭ和ＮＴＬ单用对Ｇ＋球菌的ＰＡＥ亦很明显，对大肠埃希氏菌ＰＡＥ稍短，但比单用ＡＭＰＣ要长。ＮＴＬ的ＰＡＥ比ＧＭ长，可能与受试菌对ＮＴＬ敏感性高于ＧＭ有关。三种药物ＰＡＥ均有随药物浓度增加而延长的趋势。ＡＭＰＣ与４倍ＭＩＣ的ＧＭ或ＮＴＬ联用时对受试菌的ＰＡＥ均呈协同或相加效应；对Ｇ＋球菌的联合ＰＡＥ比Ｇ－杆菌明显延长；ＡＭＰＣ与 ＮＴＬ的联合ＰＡＥ长于与 ＧＭ联合的ＰＡＥ。结论 ＡＭＰＣ与 ＧＭ或ＮＴＬ联用时延长给药间隔，仍可维持强大的抗菌活性，减轻不良反应，ＡＭＰＣ与ＮＴＬ联用优于与ＧＭ联用。
Aim The postantibiotic effects(PAEs) induced by Amoxacillin(AMPC) alone or com- bined with gentamicin(GM) or netilmycin(NTL) were studied. Methods The PAEs were determined by the spectrophotometric method. Results The PAEs induced by AM- PC alone to S. aureus and E. faecalis were long; whereas to E. coli, the PAEs were poor. PAEs induced by GM or NTL alone to Gram - positive cocci were longer than to Gram - negative bacilli. The PAEs of NTL were more obvious than those of GM. The PAEs of AMPC combined with 4× MIC of GM or NTL were all synergic or additive, and the combined PAEs to Gram - positive cocci were longer than to Gram - negative bacilli. The combined PAEs of AMPC plus NTL were more obvious than plus GM. Conclusion It is suggested that the rational prelonged dosing intervals in combinations of AMPC with two aminoglycosides should be recommended.
