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全面评估抗血管内皮生长因子药物治疗新生血管性老年性黄斑变性的影响因素,努力提高治疗效果的综合收益 被引量:18

Overall assessment of the factors influencing the effect of anti-vascular endothelial growth factor for neovascular age-related macular degeneration to improve the comprehensive benefit of treatment
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摘要 抗血管内皮生长因子(VEGF)药物治疗新生血管性老年性黄斑变性(nAMD)的疗效受多种因素影响。通过患者临床特征、影像检查结果以及对治疗反应的综合分析,可初步评估患者治疗后的可能疗效和视力恢复状况,优化治疗方案,为个体化治疗提供依据。随着基因组学、蛋白质组学和代谢组学研究的不断深入和广泛应用,这些构成现代精准医学的生物学基础将为个体化精准治疗提供更加客观准确的生物学依据。全面评估抗VEGF药物治疗nAMD的影响因素,实现“个体化、精细化”诊断治疗管理,提高治疗效果的综合收益是nAMD抗VEGF药物治疗未来努力的方向。 The therapeutic effect of anti-vascular endothelial growth factor (VEGF) for neovascular age- related macular degeneration (nAMD) was determined by a number of factors. Comprehensive thorough analysis of clinical features, imaging results and treatment response can predict the potential efficacy and possible vision recovery for the patient, and also can optimize the treatment regime to make a personalized therapy plan. Precise medicine with data from genomies, proteomies and metabolomies study will provide more objective and accurate biology basis for individual precise treatment. The future research should focus on comprehensive assessment of /actors affecting the efficacy of anti-VEGF therapy, to achieve individualized precise diagnosis and treatment, to improve the therapeutic outcome of nAMD.
作者 戴虹 卢颖毅
机构地区 北京医院眼科
出处 《中华眼底病杂志》 CAS CSCD 北大核心 2016年第1期8-11,共4页 Chinese Journal of Ocular Fundus Diseases
基金 国家自然科学基金(81441026) 北京市自然科学基金(7152123) 首都特色临床研究(Z151100004015147)
关键词 湿性黄斑变性/药物疗法 脉络膜新生血管化/药物疗法 血管生成抑制剂/治疗应用 抗体 单克隆/治疗应用 述评 Wet macular degeneration/drug therapy Choroidal neovascularization/drug therapy Angiogenesis inhibitors/therapeutic use Antibodies,monoclonal/therapeutic use Editorial
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共引文献214

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